Nuclear architecture and dynamics / edited by Christophe Lavelle, Jean-Marc Victor.

Format:

Book

Contributor:

Lavelle, Christophe, ditor.

Victor, Jean-Marc, editor.

Series:

Translational epigenetics series ; v. 2.

Translational epigenetics series ; v. 2

Language:

English

Subjects (All):

Cell nuclei.

Genre:

Electronic books.

Physical Description:

1 online resource : illustrations.

Place of Publication:

London : Academic Press, [2018]

System Details:

text file

Summary:

Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines.

Contents:

DNA mechanics

The role of nucleosome positioning in genome function and evolution

DNA supercoiling(omics)

Dynamic chromatin folding in the cell

Mesoscale modeling of chromatin fibers

A polymer physics view on universal and sequence-specific aspects of chromosome folding

Persistence of long-range contacts at insulators: turnover dynamics or engage cohesion?

Long-range intranuclear interactions

The multiple effects of molecular crowding in the cell nucleus: from molecular dynamics to the regulation of nuclear architecture

Nuclear bodies

Nucleolus: the consummate nuclear body

Transcription factories as spatial and functional organization nodes

Polycomb bodies

The nuclear lamina and genome organization

Actin in the cell nucleus

Nuclear pores and the genome

Protein transport between the nucleus and cytoplasm

Replicating chromatin in the eukaryotic genome

Promoter-enhancer looping and regulatory neighborhoods: gene regulation in the framework of topologically associating domains

Sailing the Hi-C's: benefits and remaining challenges in mapping chromatin interactions

Chromatin folding and recombination

Altered nucleus and disease

Yeast nucleus: a model for chromatin folding principles

Chromosomes and chromatin in the nematode nucleus

Nuclear dynamics at specific cell cycle stages in the slime mold Physarum polycephalum.

Notes:

Includes bibliographical references and index.

Other Format:

Print version:

ISBN:

9780128035030

012803503X

OCLC:

1006617043

Access Restriction:

Restricted for use by site license.