Overflow metabolism : from yeast to marathon runners / Alexei Vazquez.

Format:

Book

Author/Creator:

Vazquez, Alexei, author.

Language:

English

Subjects (All):

Metabolism.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

London, United Kingdom : Academic Press, an imprint of Elsevier, [2018].

System Details:

text file

Summary:

Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage.

Contents:

A historical view of overflow metabolism

Biochemical horsepower

How fast can we run?

How fast can we grow?

Overflow metabolism in human disease.

Notes:

Includes bibliographical references.

Online resource; title from PDF title page (Ebsco, viewed October 26, 2017).

Other Format:

Print version:

ISBN:

9780128123355

0128123354

OCLC:

1006380852

Access Restriction:

Restricted for use by site license.