Glyceraldehyde-3-phosphate Dehydrogenase Gapdh : the quintessential moonlighting protein in normal cell function and in human disease / Michael A. Sirover.

Format:

Book

Author/Creator:

Sirover, Michael A., author.

Language:

English

Subjects (All):

Aldehyde dehydrogenase.

Glycolysis.

Aldehyde Dehydrogenase.

Medical Subjects:

Aldehyde Dehydrogenase.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

London : Academic Press, an imprint of Elsevier, 2017.

System Details:

text file

Summary:

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein's diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease.

Contents:

Section I. The Role of Moonlighting GAPDH in Normal Cell Function. The role of moonlighting GAPDH in cell proliferation : the dynamic nature of GAPDH expression and subcellular localization

Moonlighting GAPDH and the transcriptional regulation of gene expression : multiprotein complex formation and mechanisms of nuclear translocation

The diversity of moonlighting GAPDH function in posttranscriptional RNA regulation : mRNA stability, tRNA processing, and viral pathogenesis

The role of moonlighting GAPDH in membrane structure and function : membrane fusion and iron metabolism

The role of moonlighting GAPDH in intracellular membrane trafficking : tubulin regulation and modulation of cytoskeletal structure

Moonlighting GAPDH and the maintenance of DNA integrity : preservation of genetic information and cancer facilitation

Moonlighting GAPDH in neuronal structure and function : regulation of ion channels and signal transduction

Section II. Physiological Stress and GAPDH Functional Diversity. The significance of nitric oxide-modified GAPDH : regulation of apoptosis, cell signaling, and heme metabolism

GAPDH and hypoxia : mechanisms of cell survival during oxygen deprivation

Moonlighting GAPDH and ischemia : cellular and molecular effects of oxygen deprivation and reperfusion

Section II. The Pathology of GAPDH Functional Diversity. GAPDH and tumorigenesis : molecular mechanisms of cancer development and survival

Moonlighting GAPDH and age-related neurodegenerative disease : diversity of protein interactions and complexity of function

Functional diversity of GAPDH in infection and immunity : the complexity of "simple" organisms

Moonlighting GAPDH and diabetes : pleiotropic effects of perturbations in GAPDH structure and function

Section IV. The Pharmacology of Moonlighting GAPDH

Section V. The Unique Role of Sperm-Specific GAPDH

Section VI. Discussion.

Notes:

Online resource; title from PDF title page (EBSCO, viewed June 6, 2017)

Includes bibliographical references and index.

ISBN:

9781351935623

1351935623

9780128098981

0128098988

OCLC:

988291290

Access Restriction:

Restricted for use by site license.