Nitric Oxide : Biology and Pathobiology.

Format:

Book

Author/Creator:

Ignarro, Louis J.

Contributor:

Freeman, Bruce.

Language:

English

Subjects (All):

Nitric oxide--Physiological effect.

Nitric oxide.

Nitric oxide--Therapeutic use.

Nitric Oxide--physiology.

Nitric Oxide--therapeutic use.

Medical Subjects:

Nitric Oxide--physiology.

Nitric Oxide--therapeutic use.

Genre:

Electronic books.

Physical Description:

1 online resource (436 pages)

Edition:

Third edition.

Place of Publication:

San Diego : Elsevier Science, 2017.

System Details:

text file

Contents:

Cover; Title Page; Copyright Page; Contents; Contributors; Introduction and Overview; Chapter 1

A Concise History of the Discovery of Mammalian Nitric Oxide (Nitrogen Monoxide) Biogenesis; Introduction; NO and NOx Prior to 1986; Ancient Human/NOx, NO Relationships; The Discovery of NO and 19th-Century Studies; 20th-Century NO Prior to 1986; 1986-88: Convergence of the Discovery of Endogenous NO in the Immune, Cardiovascular, and Nervous Systems; NO in the Immune System Prior to 1986-88; NO in the Cardiovascular System Prior to 1986-88; NO in the Nervous System Prior to 1986-88

The Convergence: 1986-88Conclusions; References; Chapter 2

An Integrated View of the Chemical Biology of NO, CO, H2S, and O2; Introduction; Nitric Oxide; Carbon Monoxide; Hydrogen Sulfide; Dioxygen; Superoxide; Hydrogen Peroxide; Hydroxyl Radical; Chemical Biology of NO, CO, H2S, and O2 Interactions; Interactions at Metal Centers: Heme Proteins; The Effect of O2 and Derived Species on the Chemical Biology of NO, CO, and H2S; Interaction of NO and H2S; Thiols/Thiol Proteins and NO, CO, O2, and H2S Chemical Biology; Summary; References

Chapter 3

Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art ReviewDetection of Nitric Oxide; Introduction; Detection of Nitrate and Nitrite; Griess Reaction; Chemiluminescence Detection of Nitrite/ƯNitrate; Other Methods for Nitrite/Nitrate; Probes for NO Detection; Nitronyl Nitroxides; Iron Dithiocarbamates; Diaminofluorescein (DAF); S-Nitrosothiol Detection; Detection of Liberated Nitrogen Oxides From S-Nitrosothiols; Saville Reaction; Chemiluminescence; Detection of Protein S-Nitrosothiols; Biotin Switch Assay; Other Methods

Detection of Peroxynitrite Using Boronate-Based ProbesIntroduction; Oxidation of Boronates by Peroxynitrite and Other Biologically Relevant Oxidants; Free Radical Pathway for the Reaction Between Boronates and ONOO ; Real-Time Monitoring of ONOO Formed In Situ in Cell-Free Systems; Differentiation Between Different Oxidants Using Boronic Probes; Detection of Peroxynitrite in Cellular ƯSystems; Perspectives for In Vivo Detection of Peroxynitrite; Acknowledgment; References; Chapter 4

S-Nitrosothiols and Nitric Oxide Biology; Introduction; RSNO Biochemistry: How Do RSNOs Relate to NO

S-Nitrosothiol Levels and Targets In VivoSNO Antibody; RSNO Metabolism; RSNO Formation; Transnitrosation; Denitrosation; RSNO Transport; Emerging Modulators of RSNO: Hydrogen Sulfide and Reactive Sulfur Species; Biological Effects of RSNOs-Evidence and Interpretation; RSNO Therapeutics; RSNO as NO Donors; Summary; References; Chapter 5

Cooperative Interactions Between NO and H2S: Chemistry, Biology, Physiology, Pathophysiology; Chemical Aspects of the NO/H2S Cross-Talk; Introduction; Basic Chemical Properties of Sulfide as Compared to NO

Notes:

Description based upon print version of record.

Bioactive Intermediates of the Reaction Between NO and Sulfide (and its Various Metabolites): S/N Hybrid Molecules and Poly...

Other Format:

Print version: Ignarro, Louis J. Nitric Oxide : Biology and Pathobiology

ISBN:

9780128043196

0128043199

OCLC:

999654607

Access Restriction:

Restricted for use by site license.