In vivo models to study angiogenesis / Domenico Ribatti, University of Bari Medical School, Bari, Italy, National Cancer Institute "Giovanni Paolo II", Bari, Italy.

Format:

Book

Author/Creator:

Ribatti, Domenico, 1956- author.

Language:

English

Subjects (All):

Neovascularization.

Tumors--Growth.

Tumors.

Neovascularization, Pathologic.

Disease Models, Animal.

Neoplasms--etiology.

Neoplasms--blood supply.

Medical Subjects:

Neovascularization, Pathologic.

Disease Models, Animal.

Neoplasms--etiology.

Neoplasms--blood supply.

Genre:

Electronic books.

Physical Description:

1 online resource : color illustrations

Place of Publication:

London : Academic Press, an imprint of Elsevier, [2017]

System Details:

text file

Summary:

In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available.Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling.Provides information on the most common assays to study angiogenesis in vivoPresents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and developmentCovers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant.

Contents:

The chick embryo chorioallantoic membrane

The corneal assay for angiogenesis

The matrigel implant assay

The sponge implant model

The disk angiogenesis system

The drosal air sac model

The chamber assays

The zebrafish

Animal tumor models.

Notes:

Online resource ; title from PDF title page (EBSCO, viewed September 6, 2017).

Includes bibliographical references.

Other Format:

Print version:

ISBN:

9780128140215

0128140216

OCLC:

1001728315

Access Restriction:

Restricted for use by site license.