Drug delivery : principles and applications / edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan.

Format:

Book

Contributor:

Wang, Binghe, 1962- editor.

Hu, Longqin, editor.

Siahaan, Teruna J., editor.

Series:

Wiley Series in Drug Discovery and Development

Language:

English

Subjects (All):

Drug delivery systems.

Pharmaceutical chemistry.

Physical Description:

1 online resource (894 p.)

Edition:

Second edition.

Place of Publication:

Hoboken, New Jersey : Wiley, 2016.

Language Note:

English

Summary:

Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. * Helps readers understand progress in drug delivery research and applications * Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics * Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics * Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Contents:

TITLE PAGE; TABLE OF CONTENTS; LIST OF CONTRIBUTORS; PREFACE; 1 FACTORS THAT IMPACT THE DEVELOPABILITY OF DRUG CANDIDATES; 1.1 CHALLENGES FACING THE PHARMACEUTICAL INDUSTRY; 1.2 FACTORS THAT IMPACT DEVELOPABILITY; 1.3 REMARKS ON DEVELOPABILITY; 1.4 DRUG DELIVERY FACTORS THAT IMPACT DEVELOPABILITY; REFERENCES; 2 PHYSIOLOGICAL, BIOCHEMICAL, AND CHEMICAL BARRIERS TO ORAL DRUG DELIVERY; 2.1 INTRODUCTION; 2.2 PHYSIOLOGICAL BARRIERS TO DRUG DELIVERY; 2.3 BIOCHEMICAL BARRIERS TO DRUG DELIVERY; 2.4 CHEMICAL BARRIERS TO DRUG DELIVERY

2.5 DRUG MODIFICATIONS TO ENHANCE TRANSPORT ACROSS BIOLOGICAL BARRIERS2.6 CONCLUSIONS; ACKNOWLEDGMENT; REFERENCES; 3 PHYSICOCHEMICAL PROPERTIES, FORMULATION, AND DRUG DELIVERY; 3.1 INTRODUCTION; 3.2 PHYSICOCHEMICAL PROPERTIES; 3.3 FORMULATIONS; 3.4 DRUG DELIVERY; 3.5 CONCLUSION; REFERENCES; 4 TARGETED BIOAVAILABILITY; 4.1 INTRODUCTION; 4.2 TARGET BIOAVAILABILITY; 4.3 DRUG DELIVERY TRENDS AND TARGETS RELATED TO PK AND PD; 4.4 PK-PD IN DRUG DISCOVERY AND DEVELOPMENT; 4.5 SOURCE OF VARIABILITY OF DRUG RESPONSE; 4.6 RECENT DEVELOPMENT AND ISSUES OF BIO-ANALYTICAL METHODOLOGY

4.7 MECHANISTIC PK-PD MODELS4.8 SUMMARY; REFERENCES; 5 THE ROLE OF TRANSPORTERS IN DRUG DELIVERY AND EXCRETION; 5.1 INTRODUCTION; 5.2 DRUG TRANSPORT IN ABSORPTION AND EXCRETION; 5.3 ABC (ATP-BINDING CASSETTE) TRANSPORTER FAMILY; 5.4 SLC (SOLUTE CARRIER) TRANSPORTER FAMILY; 5.5 CONCLUSIONS; ACKNOWLEDGMENT; REFERENCES; 6 INTRACELLULAR DELIVERY AND DISPOSITION OF SMALL-MOLECULAR-WEIGHT DRUGS; 6.1 INTRODUCTION; 6.2 THE RELATIONSHIP BETWEEN THE INTRACELLULAR DISTRIBUTION OF A DRUG AND ITS ACTIVITY

6.3 THE RELATIONSHIP BETWEEN THE INTRACELLULAR DISTRIBUTION OF A DRUG AND ITS PHARMACOKINETIC PROPERTIES6.4 OVERVIEW OF APPROACHES TO STUDY INTRACELLULAR DRUG DISPOSITION; 6.5 THE ACCUMULATION OF DRUGS IN MITOCHONDRIA, LYSOSOMES, AND NUCLEI; 6.6 SUMMARY AND FUTURE DIRECTIONS; REFERENCES; 7 CELL CULTURE MODELS FOR DRUG TRANSPORT STUDIES; 7.1 INTRODUCTION; 7.2 GENERAL CONSIDERATIONS; 7.3 INTESTINAL EPITHELIUM; 7.4 THE BLOOD-BRAIN BARRIER; 7.5 NASAL AND PULMONARY EPITHELIUM; 7.6 THE OCULAR EPITHELIAL AND ENDOTHELIAL BARRIERS; 7.7 THE PLACENTAL BARRIER; 7.8 THE RENAL EPITHELIUM

7.9 3D IN VITRO MODELS7.10 CONCLUSIONS; REFERENCES; 8 INTELLECTUAL PROPERTY AND REGULATORY ISSUES IN DRUG DELIVERY RESEARCH; 8.1 INTRODUCTION; 8.2 PHARMACEUTICAL PATENTS; 8.3 STATUTORY REQUIREMENTS FOR OBTAINING A PATENT; 8.4 PATENT PROCUREMENT STRATEGIES; 8.5 REGULATORY REGIME; 8.6 FDA MARKET EXCLUSIVITIES; 8.7 REGULATORY AND PATENT LAW LINKAGE; REFERENCES; 9 PRESYSTEMIC AND FIRST-PASS METABOLISM; 9.1 INTRODUCTION; 9.2 HEPATIC FIRST-PASS METABOLISM; 9.3 INTESTINAL FIRST-PASS METABOLISM; 9.4 PREDICTION OF FIRST-PASS METABOLISM; 9.5 STRATEGIES FOR OPTIMIZATION OF ORAL BIOAVAILABILITY

9.6 SUMMARY

Notes:

Revision of: Drug delivery / Binghe Wang, Teruna Siahaan, Richard Soltero. 2005.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

1-78785-089-7

1-118-83323-6

OCLC:

926623506