Sepsis : staging and potential future therapies / Christian Lehmann, Juan Zhou, Charles C. Caldwell.

Format:

Book

Author/Creator:

Lehmann, Christian (Professor of anesthesia), author.

Zhou, Juan, author.

Caldwell, Charles C., author.

Series:

Colloquium digital library of life sciences

Colloquium series on integrated systems physiology ; # 77.

Colloquium series on integrated systems physiology ; 77

Language:

English

Subjects (All):

Septicemia.

Sepsis.

Medical Subjects:

Sepsis.

Genre:

Electronic books.

Physical Description:

1 online resource (xii, 91 pages) : illustrations.

Place of Publication:

[San Rafael, California] : Morgan & Claypool, 2017.

System Details:

Mode of access: World Wide Web.

System requirements: Adobe Acrobat reader.

text file

Summary:

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical studies in this group of critically ill patients. Mainly for those reasons, there is no therapy approved so far to overcome the underlying immune dysregulation. This book provides an overview about the state of the art of sepsis diagnostics and potential future therapies. Chapter 1 focuses on the immunologic staging of sepsis--the key for successful treatment of the dysregulated hot response. Chapter 2 reveals similarities in the immune response in sepsis and cancer--opening new avenues for novel therapies. Chapter 3 introduces an important modulator of the immune response--the endogenous cannabinoid system and elucidates its role in organ dysfunction in sepsis. Facing the increasing bacterial resistance to classical antibiotics, Chapter 4 discusses two unique mechanisms to treat infection and inflammation in sepsis: iron chelation, and the sphingosine pathway. The authors, all experts in experimental and clinical sepsis research, seek to provide further understanding of the complexities of the immune response as the physiological basis for the development of new therapeutics in sepsis.

Contents:

1. Immunologic staging of sepsis: finding the right lock for the key

1.1 Introduction

1.2 Innate and adaptive immune systems

1.3 Determining the immune status of patients with flow cytometry

1.4 Conclusion

2. Sepsis and cancer: similarities in the immune response and treatment with novel therapies

2.1 Introduction

2.2 Shared mechanisms in inflammation and immunosuppression

2.2.1 Mechanisms of immunomodulation

2.2.2 T-cell anergy

2.2.3 T-cell exhaustion

2.3 Programmed cell death 1 (PD-1, CD279)

2.3.1 The role of PD-1 in cancer

2.4 Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4, CD152)

2.4.1 The role of CTLA-4 in cancer

2.4.2 The role of CTLA-4 in sepsis

2.5 Interleukin-7 (IL-7)

2.5.1 The biology of IL-7

2.5.2 The role of IL-7 in murine models of sepsis

2.5.3 Therapeutic application of IL-7 to human trials

2.6 TNF-a

2.6.1 Therapeutic application of TNF to human trials

2.7 Anti-LPS

2.8 IL-1B

3. Organ dysfunction and the endocannabinoid system in sepsis

3.1 Abstract

3.2 Introduction

3.2.1 The endocannabinoid system (ECS)

3.2.2 Sepsis

3.2.3 State of sepsis treatments and sepsis-specific biomarkers

3.2.4 Death in sepsis and the role of immune paralysis in death

3.3.5 Studies on ECS and survival in sepsis

3.3 Immune system

3.3.1 Immune dysfunction in the sepsis patient

3.3.2 Role of the ECS in sepsis-related immune dysfunction

3.4 Cardiovascular dysfunction in sepsis

3.4.1 Cardiovascular compromise and sepsis

3.4.2 Role of the ECS in cardiovascular dysfunction during sepsis

3.5 Gastrointestinal dysfunction in sepsis

3.5.1 Gastrointestinal compromise and sepsis

3.5.2 Role of the ECS in gastrointestinal dysfunction during sepsis

3.6 Respiratory dysfunction in sepsis

3.6.1 Respiratory compromise and sepsis

3.6.2 Role of the ECS in respiratory dysfunction during sepsis

3.7 Summary of ECS-based therapeutics

4. Novel antibiotic approaches in sepsis

4.1 Introduction

4.2 Physiologic roles of iron

4.3 Iron chelation in sepsis

4.4 Potential mechanisms

4.5 Pharmacological considerations

4.6 Antimicrobial effect of sphingosine

5. Summary

References

Chapter 1 references

Chapter 2 references

Chapter 3 references

Chapter 4 references

Lead author biographies

Contributing author biographies.

Notes:

Part of: Colloquium digital library of life sciences.

Includes bibliographical references (pages 59-87).

Title from PDF title page (viewed on October 3, 2017).

Other Format:

Print version:

ISBN:

9781615047574

OCLC:

1005265591

Access Restriction:

Restricted for use by site license.