Tendon regeneration : understanding tissue physiology and development to engineer functional substitutes / edited by Manuela E. Gomes, Rui L. Reis, Márcia T. Rodrigues.

Format:

Book

Contributor:

Gomes, Manuela E., editor.

Reis, Rui L., editor.

Rodrigues, Márcia, editor.

ScienceDirect (Online service)

Mary M. Kaufman Memorial Fund for Neuro-Science & Biomedical Engineering Source.

Language:

English

Subjects (All):

Tendons.

Tendons--Wounds and injuries--Healing.

Physical Description:

1 online resource

polychrome

Place of Publication:

London : Elsevier, [2015]

System Details:

text file

Summary:

A multidisciplinary approach to tissue engineering and regenerative medicine (TERM) strategies in tendon regeneration. Key Feature, Provides on overview of tendon biology, mechanobioloyy, disease, and current repair therapies, Modern alternative approaches to regenerate tendon tissue, Tissue engineering approaches for developing functional tissue substitutes, Development of tissue-engineering products using TERM strategies discussed, Tendon Regeneration is the first book of its kind to highlight the multidisciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue substitutes following TERM strategies. Beginning with a foundation in developmental biology, this book explores physiology, pathology, and surgical reconstruction, building in a natural progression to provide guidance on biological approaches to enhance tendon regeneration practices. Contributions from scientists, clinicians, and engineers, who are all leading figures in their fields, provide recent findings in stem cells therapies, scaffold augmentation, and tissue engineering approaches, as well as examples of preclinical models for translational therapies and a view of the future of the field. Book jacket.

Contents:

Section 1 Biology and Physiology of Tendons 1

1 Tendon Physiology and Mechanical Behavior: Structure-Function Relationships / Chavaunne T. Thorpe Thorpe, Chavaunne T., Helen L. Birch Birch, Helen L., Peter D. Clegg Clegg, Peter D., Hazel R.C. Screen Screen, Hazel R.C. 3

1 Tendon Structure and Composition 4

2 Tendon Mechanics 10

3 Muitiscale Mechanics and Structure-Function Characterization 17

4 Mechanical and Compositional Variations in Tendons with Different Functions 24

List of Abbreviations 35

Glossary 35

References 35

2 Tendon Resident Cells-Functions and Features in Section 1-Developmental Biology and Physiology of Tendons / Benjamin B. Rothrauff Rothrauff, Benjamin B., Guang Yang Yang, Guang, Rocky S. Tuan Tuan, Rocky S. 41

1 Introduction 41

2 Tendon Cells-Origin and Specification 42

3 Tendon Cells-ECM Synthesis, Assembly, and Tissue Maturation 49

4 Cell-ECM Interactions 56

5 Mechanoregulation of Tendon Cells 66

6 Conclusion 70

List of Abbreviations 70

Glossary 71

References 72

3 Mechanobiology of Embryonic and Adult Tendons / Laura A. Hockaday Hockaday, Laura A., Mitchell D. Saeger Saeger, Mitchell D., Faith W. Karanja Karanja, Faith W., Catherine K. Kuo Kuo, Catherine K. 77

1 Introduction 78

2 Embryonic Tendon 79

3 Postnatal Tendon 83

4 Mechanical Cues Experienced by Embryonic, Postnatal, and Adult Tendons 84

5 Studies in the Embryo Suggest Mechanical Factors Influence Embryonic Tendon Development 90

6 In Vitro Studies Suggest Mechanical Factors Influence Embryonic Tendon Development 91

7 Exercise Studies Examine the Influence of Mechanics in Adult Tendon 94

8 In Vitro Studies Suggest Mechanical Factors Influence Adult Tendon Homeostasis 98

9 Potential Mechanisms of Tendon Cell Mechanotransduction 101

10 Conclusions 103

List of Abbreviations 103

References 104

Section 2 Pathologies and Repair of Tendons 111

4 Tendinopathy I: Understanding Epidemiology, Pathology, Healing, and Treatment / Paul W. Ackermann Ackermann, Paul W. 113

1 Introduction 114

2 Anatomical Diagnosis 115

3 Pathology 116

4 Epidemiology 119

5 Pathophysiology 122

6 Healing and Repair 126

7 Nonsurgical Treatment 134

8 Surgical Treatment 140

9 Conclusion 141

List of Abbreviations 142

Glossary 143

References 144

5 Tendinopathy II: Etiology, Pathology, and Healing of Tendon Injury and Disease / Corinne N. Riggin Riggin, Corinne N., Tyler R. Morris Morris, Tyler R., Louis J. Soslowsky Soslowsky, Louis J. 149

1 Epidemiology 150

2 Definitions 150

3 Tendinopathy Etiology 154

4 Pathology 160

5 Summary and Conclusions 176

List of Abbreviations 176

Glossary 177

References 178

Section 3 Tendon Regenerative Medicine Approaches 185

6 Cell-Based Approaches for Tendon Regeneration / Ana I. Goncaives Goncaives, Ana I., Raquel Costa-Almeida Costa-Almeida, Raquel, Pavel Gershovich Gershovich, Pavel, Márcia T. Rodrigues Rodrigues, Márcia T., Rui L. Reis Reis, Rui L., Manuela E. Gomes Gomes, Manuela E. 187

1 Introduction 187

2 Tendon Endogenous Regeneration 188

3 Isolation Procedures of Tendon Resident Cells 191

4 Alternative Stem Cells Sources for Cell-Based Tendon Tissue Engineering 193

5 Moving Cell Therapies into the Clinics 197

6 Conclusion 198

List of Abbreviations 199

Glossary 200

References 200

7 The Role of Growth Factors in Tendon Stimulation / Pietro Randelli Randelli, Pietro, Alessandra Menon Menon, Alessandra, Vincenza Ragone Ragone, Vincenza, Riccardo D'Ambrosi D'Ambrosi, Riccardo, Filippo Randelli Randelli, Filippo, Paolo Cabitza Cabitza, Paolo, Giuseppe Banfi Banfi, Giuseppe 205

1 Introduction 205

2 Growth Factors 206

3 Platelet-Rich Plasma 209

4 Conclusions 216

List of Abbreviations 217

References 217

Section 4 Scaffolds-Based Approaches 223

8 Engineering Anisotropic 2D and 3D Structures for Tendon Repair and Regeneration / Alex Lomas Lomas, Alex, Andrew English English, Andrew, Manus Biggs Biggs, Manus, Abhay Pandit Pandit, Abhay, Oimitrios I. Zeugolis Zeugolis, Oimitrios I. 225

1 Introduction 225

2 Anisotropic Sponges 226

3 Anisotropic Self-Assembled Fibers 227

4 Anisotropic Electrospun Fibers 228

5 Anisotropic imprinted Substrates 231

6 Conclusive Remarks 233

List of Abbreviations 233

Glossary 234

Acknowledgments 234

References 234

9 Biologic-and Synthetic-Based Scaffolds for Tendon Regeneration / Sambit Sahoo Sahoo, Sambit 243

1 Tendon Injuries 243

2 Tendon Repair and Tissue Engineering Strategies 244

3 Criteria and Requirements for Tendon Tissue Engineering Scaffolds 244

4 Types for Tendon Tissue Engineering Scaffolds 245

5 Scaffold Architecture and Design 249

6 Functional and Bioactive Scaffolds 251

7 Conclusions 251

List of Abbreviations 252

References 252

Section 5 Tendon Tissue Engineering 257

10 Fabrication of Hierarchical and Biomimetic Fibrous Structures to Support the Regeneration of Tendon Tissues / Rui M.A. Domingues Domingues, Rui M.A., Ana I. Goncalves Goncalves, Ana I., Raquel Costa-Almeida Costa-Almeida, Raquel, Marcia T. Rodrigues Rodrigues, Marcia T., Rui L. Reis Reis, Rui L., Manuela E. Gomes Gomes, Manuela E. 259

7 Introduction 259

2 Spinning Techniques for Tendon TE Scaffolding 261

3 Rapid Prototyping Technique 268

4 Electrochemically Aligned Collagen 269

5 Microengineered Hydrogels 270

6 Assembly of Fibrous Biomaterials into Higher Hierarchical Structures 273

7 Concluding Remarks and Future Perspectives 274

List of Abbreviations 276

Glossary 277

References 277

11 Multifactorial Tendon Tissue Engineering Strategies / Thomas D. Kwan Kwan, Thomas D., Alicia J. El Haj Haj, Alicia J. El 281

1 Introduction 281

2 Cells, Scaffolds, and Mechanical Stimulation 283

3 Approaches for Different Anatomical Regions 301

4 Design of Custom Bioreactors 309

5 Concluding Remarks 312

List of Abbreviations 312

Glossary 313

References 314

12 Tendon Tissue Engineering: Combined Tissue Engineering Approach for the Regeneration of Tendons / Brandon Engebretson Engebretson, Brandon, Zachary Mussett Mussett, Zachary, Cortes Williams Williams, Cortes, Aaron Simmons Simmons, Aaron, Vassilios Sikavitsas Sikavitsas, Vassilios 321

1 Introduction 322

2 Functional Tendon Tissue Engineering 325

3 Tendon Tissue Engineering Bioreactors and Construct Stimulation 336

4 Conclusions 341

List of Abbreviations 342

Glossary 342

Acknowledgments 343

References 343

13 Biomaterial Scaffolds for Tendon Tissue Engineering / Rebecca Hortensius Hortensius, Rebecca, Laura Mozdzen Mozdzen, Laura, Brendan Harley Harley, Brendan 349

1 Motivation: Tendon Injury and Repair Mechanism 349

2 Introduction to Tissue Engineering 353

3 Cell-Biomaterial Interactions 359

4 Clinical Translation and Adaptation to Complex Musculoskeletal Injury Models 367

5 Conclusions 370

List of Abbreviations 370

Glossary 371

Acknowledgments 372

References 372

14 Engineered Tendon Repair and Regeneration / Wei Liu Liu, Wei, Bin Wang Wang, Bin, Yilin Cao Cao, Yilin 381

1 Introduction 381

2 Cell Sources in Tendon Engineering and Regeneration 382

3 Scaffold Materials for Tendon Engineering 388

4 In Vivo, In Vitro, and Ex Vivo Tendon Engineering 393

5 Conclusion 407

List of Abbreviations 408

Glossary 409

Acknowledgments 409

References 409

15 Scaffold Design for Integrative Tendon-Bone Repair / Xinzhi Zhang Zhang, Xinzhi, William N. Levine Levine, William N., Helen H. Lu Lu, Helen H. 413

1 Introduction 413

2 Rotator Cuff Tendon Augmentation Grafts 415

3 Integrative Rotator CuffTendon-Bone Repair 419

4 Summary and Future Directions 427

List of Abbreviations 428

References 428.

Notes:

Electronic reproduction. Amsterdam Available via World Wide Web.

Vendor-supplied metadata.

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Mary M. Kaufman Memorial Fund for Neuro-Science & Biomedical Engineering Source.

ISBN:

9780128016008

0128016000

Publisher Number:

99974132776

Access Restriction:

Restricted for use by site license.