Notch Signaling : Immunity and Cancer / edited by Koji Yasutomo.

Format:

Book

Contributor:

Yasutomo, Koji, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Cancer--Research.

Cancer.

Immunology.

Biomedicine.

Local Subjects:

Biomedicine.

Physical Description:

1 online resource

Contained In:

Springer eBooks

Place of Publication:

Singapore : Springer Singapore : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry.

Contents:

Preface

Part I Immunology

Ch1 Notch ligands for lymphocyte development

Ch2 Notch controls the differentiation and function of cytotoxic CD8 T cells

Ch3 Notch and myeloid cells

Ch4 Taking CD4 T cells up a Notch

Part II Cancer

Ch5 NOTCH in malignant lymphoma

Ch6 The two faces of Notch in solid cancers.

Other Format:

Printed edition:

ISBN:

9789811049712

Access Restriction:

Restricted for use by site license.