Antimicrobial Drug Resistance : Clinical and Epidemiological Aspects, Volume 2 / edited by Douglas L. Mayers, Jack D. Sobel, Marc Ouellette, Keith S. Kaye, Dror Marchaim.

Format:

Book

Contributor:

Mayers, Douglas L., editor.

Sobel, Jack D., editor.

Ouellette, Marc, editor.

Kaye, Keith S., editor.

Marchaim, Dror, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Drug resistance.

Infectious diseases.

Biomedicine.

Local Subjects:

Biomedicine.

Physical Description:

1 online resource

Edition:

Second edition 2017.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.

Contents:

History of Drug-Resistant Microbes

Evolutionary Biology of Drug Resistance

Pharmacology of Drug Resistance

Drug Development for Drug-Resistant Pathogens

Genetic Mechanisms of Transfer of Drug Resistance

Mutations as a Basis of Antimicrobial Resistance

Altered Drug Targets

Enzymatic Modification of Drugs

Reduced Drug Penetration

Active Efflux Mechanism

Biofilms

Beta-Lactamases

Penicillin Binding Proteins

Aminoglycosides

Tetracyclines and ChloramphenicolQuinolones

Plasmid Mediated Quinolone Resistance to Macrolides, Lincosamides, and Streptogramins

Mechanisms of Resistance in Metronidazole

Glycopeptide-resistance in eneterococci

Daptomycin Resistance

Oxazolidinones

PolymyxinsSulfonamides and Trimethoprim

Antimycobacterial Agents

Amphotericin (Polyenes)

Azoles

Flucytosine

Echinocandins

Antifungal Targets, Mechanisms of Action, and Resistance in Candida albicans

Herpes Nucleoside Drugs

Influenza Drugs

HIV Nucleoside Drugs

HIV Non-Nucleoside Drugs

HIV Protease Inhibitors

HIV Entry Inhibitors

HIV Integrase Inhibitors

Hepatitis B

Hepatitis C

Agents for anaerobic protozoa

Antimalarial Agents

Agents for Leishmania

Agents for Trypanosomes

Agents for Toxoplasma

Agents for Cryptosporidium

Agents against Nematodes

Agents against Trematodes and Cestodes

Agents against Ectoparasites.

Other Format:

Printed edition:

ISBN:

9783319472669

Access Restriction:

Restricted for use by site license.