Photoaffinity Labeling for Structural Probing Within Protein / edited by Yasumaru Hatanaka, Makoto Hashimoto.

Format:

Book

Contributor:

Hatanaka, Yasumaru, editor.

Hashimoto, Makoto (Professor of applied bioscience), editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Pharmaceutical technology.

Biochemical engineering.

Biomedicine.

Local Subjects:

Biomedicine.

Physical Description:

1 online resource

Contained In:

Springer eBooks

Place of Publication:

Tokyo : Springer Japan : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labeled products, and recent successful applications for protein probing. Regarding drug design, the unique topics of the book are the special consideration of the crosslinking potential of recent probes and their application of important receptor proteins . This book presents emerging technologies of photoaffinity labeling to readers who are working in the fields of proteomics, molecular recognition, and drug discovery and development.

Contents:

Preface

Chapter 1 Multifunctional Photoprobes for Identification of Ligand Sites within Biomolecules

Chapter 2 Tag-Creation Approaches for Highly Efficient Profiling of Interacting Proteins and Domains

Chapter 3 Recent Developments in Designing Compact Biological Photoprobes

Chapter 4 Utilities of Anti-Ligand Antibody and Mass Spectrum to Elucidate Photolabelled Sites

Chapter 5 Combination of Photoaffinity Label and Site-Directed Antibody for Target Proteins

Chapter 6 Synthesis of diazirinyl photophore and optically pure diazirinylphenylalanines for photoaffinity labeling

Chapter 7 Photoreactive biomacromolecules: preparation using photoreactive units and applications for analyzing biological interfaces

Chapter 8 Covalently capturing protein interactions in living cells by site-specific incorporation of photo-cross-linkable amino acids

Chapter 9 Use of hexose photolabels to reveal the structure and function of glucose transporters

Chapter 10 The function of the mammalian peroxisome and analysis of the fatty acid oxidation system by photoaffinity labeling

Chapter 11 Photoaffinity labeling methods to explore internalization mechanisms of arginine-rich cell-penetrating peptides

Chapter 12 Photoaffinity Labeling in Drug Discovery Research.

Other Format:

Printed edition:

ISBN:

9784431565697

Access Restriction:

Restricted for use by site license.