Non-canonical Cyclic Nucleotides / edited by Roland Seifert.

Format:

Book

Contributor:

Seifert, Roland, editor.

SpringerLink (Online service)

Series:

Handbook of experimental pharmacology 0171-2004 ; 238.

Handbook of Experimental Pharmacology, 0171-2004 ; 238

Language:

English

Subjects (All):

Medicine.

Human physiology.

Pharmacology.

Biochemistry.

Biomedicine.

Local Subjects:

Biomedicine.

Physical Description:

1 online resource.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

The cyclic purine nucleotides 3',5'-cAMP and 3',5'-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3',5'-cAMP and 3',5'-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3',5'-cCMP and 3',5'-cUMP, the purine nucleotide 3',5'-cIMP, the 2',3'-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3',5'-cCMP and 3',5'-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3',5'-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Contents:

Part I: 3',5'-cCMP and 3',5'-cUMP as second messengers: cCMP and cUMP across the tree of life: From cCMP and cUMP generators to cCMP- and cUMP-regulated cell functions

cCMP and cUMP in apoptosis: Concepts and methods

Mammalian nucleotidyl cyclases and their nucleotide binding sites

The Pseudomonas aeruginosa exoenzyme Y: A promiscuous nucleotidyl cyclase edema factor and virulence determinant

Cyclic nucleotide monophosphates in plants and plant signalling

cAMP-dependent protein kinase and cGMP-dependent protein kinase as cyclic nucleotide effectors

Regulation of HCN ion channels by non-canonical cyclic nucleotides

Identification of cCMP and cUMP substrate proteins and cross-talk between cNMPs

Inactivation of non-canonical cyclic nucleotides: Hydrolysis and transport

Part II: 3',5'-cIMP, 8-nitro-cGMP, 2',3'-cNMPs and cyclic dinucleotides as signaling molecules: 3',5'-cIMP as potential second messenger in the vascular wall

The discovery of 2',3'-cNMPs in mammalian systems: From rodents to humans

8-Nitro-cGMP: A novel protein-reactive cNMP and its emerging roles in autophagy

Cyclic dinucleotides in the scope of the mammalian immune system

Part III: Methods/Tools for cNMP research: Mass-spectrometric analysis of non-canonical cyclic nucleotides

Medicinal chemistry of the noncanonical cyclic nucleotides cCMP and cUMP

Holistic methods for the analysis of cNMP effects

The chemistry of the non-canonical cyclic dinucleotide 2'3'-cGAMP and its analogs.

Other Format:

Printed edition:

ISBN:

9783319526737

Access Restriction:

Restricted for use by site license.