Squamous cell Carcinoma : Molecular Therapeutic Targets / edited by Saman Warnakulasuriya, Zakir Khan.

Format:

Book

Contributor:

Warnakulasuriya, S. (Saman), editor.

Khān, Jākir, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Cancer--Research.

Cancer.

Biomedicine.

Local Subjects:

Biomedicine.

Physical Description:

1 online resource

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.

Contents:

Preface

Foreword.-Introduction- The biology and pathology of squamous cell carcinomata in the head and neck

Cancer Stem Cells - Biopathology with reference to Head and Neck Cancers

Hypoxia in head and neck cancer

Genetic aberrations and molecular pathways in head and neck cancer

p53 in Head and Neck Squamous Cell Carcinoma

Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck

Targeting the mTOR signaling circuitry in head and neck cancer

Survivin as a Therapeutic Target in Squamous Cell Carcinoma

MicroRNA: utility as biomarkers and therapeutic targets in squamous cell carcinoma

Envoi - An appraisal of Targeted Therapies for Head and Neck Cancer

Index.

Other Format:

Printed edition:

ISBN:

9789402410846

Access Restriction:

Restricted for use by site license.