2 options
Transient Receptor Potential Canonical Channels and Brain Diseases / edited by Yizheng Wang.
LIBRA Per. v.1 (1967)-v.111 (1979) v.112 (1980)-v.267 (1990), v.269 (1990)-v.330 (1993), v.332 (1993)-v.363 (1995), v.365 (1994)-v.367 (1995), v.369 (1995)-v.370 (1994), v.371B (1995), v.372 (1995)-v.373 (1995), v.375 (1995)-v.401 (1996), v.403 (1996), v.406 (1997), v.408 (1997)-v.482 (2000)-v.483 (2000)
Available from offsite location
Holman Biotech Commons R850.A1 A39 v.484 (2001)-v.506 Pt.A (2002), v.506 Pt.B (2002), v.507 (2002)-v.538 (2003), v.539 Pt.A-B (2003), v.540 (2003)-v.554 (2004), v.557 (2006)-v.561 (2005), v.563 (2005)-v.585 (2006),v.587 (2006)-v.600 (2007), v.601 (2007)-v.611 v.612-v.664,v.669-v.681,v.682-v.687,v.689-v.694,v.696-v.698,v.700-v.730,v.732-v.740,v.742-v.751,v.754-v.758,v.760,v.762-v.765,v.767-v.771,v.774-v.780,v.782-v.788,v.790,v.942,v.946,v.954,v.961,v.970,v.984-v.986,v.990-v.992
Mixed Availability
- Format:
- Book
- Series:
- Advances in experimental medicine and biology 0065-2598 ; 976.
- Advances in experimental medicine and biology
- Language:
- English
- Subjects (All):
- Medicine.
- Cancer--Research.
- Cancer.
- Neurosciences.
- Pharmacology.
- Biochemistry.
- Biomedicine.
- Local Subjects:
- Biomedicine.
- Physical Description:
- 1 online resource.
- Contained In:
- Springer eBooks
- Place of Publication:
- Dordrecht : Springer Netherlands : Imprint: Springer, 2017.
- System Details:
- text file PDF
- Summary:
- This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians. What sets TRPCs apart from other subfamilies in TRPs is that their activation, stimulated by a membrane receptor-phospholipid C (PLC) cascade, contributes to the slow and sustained elevation of intracellular free calcium. Calcium ions, one of the most important types of second messengers, mediate a variety of physiological functions in the brain, including progenitor cell proliferation, dendritic formation, synaptic transmission and neuronal survival. All TRPCs except TRPC7 have been found in various regions of the brain, including the cerebrum, cerebellum, forebrain and hippocampus. This book provides students and investigators with comprehensive information on the regulation, function and potential of TRPCs and brain diseases in order to attract more attention to this field.
- Contents:
- TRP channel classification
- TRPC channel structure and properties
- TRPC channel downstream signaling cascades
- TRPC Channels in Health and Disease
- TRPC channels and programmed cell death
- TRPC channels and stroke
- TRPC channels and Alzheimer's disease
- TRPC channels and Parkinson's disease
- TRPC channels and neuron development, plasticity and activities
- TRPC channels and brain inflammation
- TRPC channels and Epilepsy
- TRPC channels and mental disorders
- TRPC channels and cell proliferation
- TRPC channels and glioma.
- Other Format:
- Printed edition:
- ISBN:
- 9789402410884
- Access Restriction:
- Restricted for use by site license.
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.