Bone Toxicology / edited by Susan Y. Smith, Aurore Varela, Rana Samadfam.

Format:

Book

Contributor:

Smith, Susan Y., editor.

Varela, Aurore, editor.

Samadfam, Rana, editor.

SpringerLink (Online service)

Series:

Molecular and integrative toxicology 2168-4219

Molecular and Integrative Toxicology, 2168-4219

Language:

English

Subjects (All):

Medicine.

Pharmacology.

Pharmaceutical technology.

Animal models in research.

Biomedicine.

Local Subjects:

Biomedicine.

Physical Description:

1 online resource.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

Contents:

Bone Toxicology in Preclinical Drug Testing

Bone Physiology and Biology

Study designs and Regulatory Considerations

Specific Considerations for Bone Evaluations for Pediatric Therapeutics

Bone Pharmacology and other models in Preclinical Drug Testing

Methods in Bone Toxicology

Biochemical Markers and Hormones

Imaging

Biomechanics

Pathology and Histomorphometry

Integrated System Toxicology

Bone and Muscle

Bone and Reproductive System

Bone and Kidneys

Bone and Energy Metabolism

Bone and Immune System

Bone and Central Nervous System

Bone and Other Organs.

Other Format:

Printed edition:

ISBN:

9783319561929

Access Restriction:

Restricted for use by site license.