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Resistance to Molecular Therapies for Hepatocellular Carcinoma / edited by Augusto Villanueva.
- Format:
- Book
- Series:
- Resistance to targeted anti-cancer therapeutics 2196-5501 ; 13.
- Resistance to Targeted Anti-Cancer Therapeutics, 2196-5501 ; 13
- Language:
- English
- Subjects (All):
- Medicine.
- Cancer--Research.
- Cancer.
- Biomedicine.
- Local Subjects:
- Biomedicine.
- Physical Description:
- 1 online resource.
- Contained In:
- Springer eBooks
- Place of Publication:
- Cham : Springer International Publishing : Imprint: Springer, 2017.
- System Details:
- text file PDF
- Summary:
- This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.
- Contents:
- Tumor Heterogeneity and Resistance to Targeted Therapies in Hepatocellular Carcinoma
- Modulating Immune Responses to Overcome Resistance in Hepatocellular Carcinoma
- Role of Tumor Microenvironment in Hepatocellular Carcinoma Resistance
- Contribution of the Cancer Stem Cell Phenotype to Hepatocellular Carcinoma Resistance
- Clinical and Preclinical Perspectives on Mechanisms of Sorafenib Resistance in Hepatocellular Carcinoma
- Radiological Assessment of Response to Palliative Treatments in Hepatocellular Carcinoma
- Sorafenib and Clinical Patterns of Resistance in hepatocellular carcinoma
- Overcoming Treatment Resistance in Hepatocellular Carcinoma: regorafenib and lessons from other malignancies.
- Other Format:
- Printed edition:
- ISBN:
- 9783319561974
- Access Restriction:
- Restricted for use by site license.
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