Viral proteases and their inhibitors / edited by Satya P. Gupta.

Format:

Book

Contributor:

Gupta, Satya Prakash.

ProQuest ebook central.

Language:

English

Subjects (All):

Viral proteinases--Inhibitors.

Viral proteinases.

Virus inhibitors.

Antiviral agents.

Physical Description:

1 online resource

Place of Publication:

London, United Kingdom : Academic Press is an imprint of Elsevier, [2017]

System Details:

text file

Contents:

Cover; Title Page; Copyright Page; Contents; Contributors; Preface; Chapter 1

Fundamentals of Viruses and Their Proteases; 1

Introduction; 2

Biochemistry of proteases; 3

Viruses; 3.1

Enveloped/Nonenveloped Viruses; 3.2

DNA and RNA Viruses; 4

Viruses containing proteases; 4.1

Adenoviruses; 4.1.1

Adenovirus Protease; 4.2

Alphaviruses; 4.3

Flaviviruses; 4.3.1

NS2B-NS3 Protease; 4.3.2

NS3 NTPase/RNA Helicase (NS3hel); 4.4

Hepatitis C Virus; 4.4.1

HCV Protease; 4.5

Herpes Viruses; 4.5.1

Herpesvirus Protease; 4.6

Human Immunodeficiency Virus of Type 1

4.6.1

HIV1 Protease4.7

Picornaviruses; 4.7.1

Picornavirus Proteases; 5

Conclusions; References; Further Reading; Chapter 2

Design and Development of Some Viral Protease Inhibitors by QSAR and Molecular Modeling Studies; 1

Quantitative structure-activity relationship; 3

Viral proteases; 3.1

Adenoviruses; 3.1.1

Adenovirus Protease AVP (Adenain) Structure and Function; 3.1.2

Adenoviral Protease AVP (Adenain) Inhibitors; 3.2

Hepatitis C Virus; 3.2.1

NS3 Protease Structure and Function; 3.2.2

NS3 Protease Inhibitors; 3.3

Human-Immunodeficiency Virus

3.3.1

HIV Protease Structure and Function3.3.2

HIV Protease Inhibitors; 3.4

Picornavirus; 3.4.1

Picornavirus Protease Structure and Function; 3.4.2

Picornavirus Protease Inhibitors; 4

Conclusions; References; Further reading; Chapter 3

Advances in Studies on Adenovirus Proteases and Their Inhibitors; 1

Adenovirus life cycle; 3

Adenovirus maturation protease; 4

Structure of AVP; 5

AVP inhibitors; 6

Conclusions; References; Chapter 4

Alphavirus Nonstructural Proteases and Their Inhibitors; 1

Alphaviruses; 2.1

Life Cycle of Virus

2.2

Alphavirus and its Virion Structure3

Global vision of nonstructural proteins; 3.1

NSP1 Protease Inhibitors; 3.1.1

Bone Marrow Stromal Antigen-2-Based Inhibitors; 3.1.2

Small Hairpin RNA Molecules; 3.2

NSP2 Inhibitors; 3.2.1

Natural Inhibitors; 3.2.2

Druggable Targets Peptides; 3.2.3

NSP2-Based High-Throughput Screening; 3.2.4

Thienopyrrole Derivatives; 3.2.5

Thiazolidone Derivatives; 3.3

NSP3 Protease Inhibitors; 3.3.1

Natural Inhibitors for NSP3 Protease; 3.4

NSP4 Protease Inhibitors; 3.4.1

Nucleoside and Nonnucleoside Inhibitors

4

Concluding remarks and future perspectivesAcknowledgments; References; Further Reading; Chapter 5

Structure and Function of Alphavirus Proteases; 1

Alphavirus proteases; 3

Capsid protease; 3.1

Proteolytic Mechanism; 3.2

Structure of Capsid Protease; 3.2.1

The Hydrophobic Pocket; 3.2.2

The Catalytic Triad; 3.2.3

The Oxyanion Hole; 3.2.4

Specificity Pockets; 3.3

trans-Protease Activity and High Throughput Inhibitor Screening Assay; 3.4

Capsid Protease Inhibition; 4

nsP2 protease; 4.1

Mechanism; 4.2

Crystal Structures of nsP2 Protease

4.2.1

VEEV nsP2 Protease Structure

Notes:

Electronic reproduction. Ann Arbor, MI Available via World Wide Web.

ISBN:

0128096829

9780128096826

Publisher Number:

99978157568

Access Restriction:

Restricted for use by site license.