Rethinking homeostasis : allostatic regulation in physiology and pathophysiology / Jay Schulkin.

Format:

Book

Author/Creator:

Schulkin, Jay, author.

Language:

English

Subjects (All):

Biological control systems.

Homeostasis.

Neuroendocrinology.

Psychophysiology.

Physical Description:

1 online resource (xvi, 296 pages) : illustrations

Other Title:

MIT Press CogNet.

Place of Publication:

Cambridge, Massachusetts : The MIT Press, [2003]

System Details:

text file

Summary:

Homeostasis, a key concept in biology, refers to the tendency toward stability in the various bodily states that make up the internal environment. Examples include temperature regulation and oxygen consumption. The body's needs, however, do not remain constant. When an organism is under stress, the central nervous system works with the endocrine system to use resources to maintain the overall viability of the organism. The process accelerates the various systems' defenses of bodily viability, but can violate short-term homeostasis. This allostatic regulation highlights our ability to anticipate, adapt to, and cope with impending future events. In Rethinking Homeostasis, Jay Schulkin defines and explores many aspects of allostasis, including the wear and tear on tissues and accelerated pathophysiology caused by allostatic overload. Focusing on the concept of motivation and its relationship to central nervous system function and specific hormonal systems, he applies a neuroendocrine perspective to central motive states such as cravings for water, sodium, food, sex, and drugs. He examines in detail the bodily consequences of the behavioral and neuroendocrine regulation of fear and adversity, the endocrine regulation of normal and preterm birth, and the effects of drug addiction on the body. Schulkin's presentation of allostasis lays the foundation for further study.

Contents:

Chapter 1 Allostasis: The Emergence of a Concept 1

Chapter 2 Central Motive States: Feedforward Neuroendocrine Systems in the Brain 29

Chapter 3 Anticipation, Angst, Allostatic Regulation: Adrenal Steroid Regulation of Corticotropin-Releasing Hormone 63

Chapter 4 Normal and Pathological Facilitation of Parturition by a Feedforward Endocrine Mechanism 103

Chapter 5 Addiction to Drugs: Allostatic Regulation under Duress 131

Conclusion: Adaptation, Allostasis, and Anticipation 161.

Notes:

"A Bradford book."

Includes bibliographical references (pages 175-277) and indexes.

Description based on print version record.

Other Format:

Print version: Schulkin, Jay. Rethinking homeostasis.

ISBN:

9780262283274

0262283271

Access Restriction:

Restricted for use by site license.