The intact and sliced brain / Mircea Steriade.

Format:

Book

Author/Creator:

Steriade, Mircea, author.

Language:

English

Subjects (All):

Brain--Physiology.

Brain.

Brain--Research--Methodology.

Neurophysiology.

Brain--Research.

Physical Description:

1 online resource (xi, 366 pages, 12 unnumbered pages of plates) : illustrations (some color)

Other Title:

MIT Press CogNet.

Place of Publication:

Cambridge, Massachusetts : The MIT Press, [2001]

System Details:

text file

Summary:

In this book, Mircea Steriade cautions against the tendency to infer global brain functions, normal and pathological, from the properties of single neurons or simple networks. Studies on extremely simplified preparations, he argues, led to a climate in which isolated neuronal networks and even single neurons are sometimes considered responsible for complex physiological processes that arise naturally from interconnections between many brain structures. These interconnections cannot be seen in brain slices. Based on his lifetime of research, Steriade emphasizes the need to integrate information obtained, from studies of simple circuits within the context of an intact brain. Despite the degree to which knowledge of brain structure and function have progressed, he views skeptically the quest to relate consciousness to specific neuronal types, located in distinct cortical layers or in circumscribed neuronal systems.

The books sections are Changing Concepts of Localization of Brain Function, Evolution of Methods in Brain Studies, Similar and Contrasting Results from Studies in the Intact and Sliced Brain, Building Blocks of Synaptic Networks Underlying Normal and Paroxysmal States, and Of Neurons and Consciousness.

Contents:

Chapter 1 Changing Concepts on Localization of Brain Functions 1

1.1 Command Neurons, Brain Centers, and Complex Neuronal Circuits Underlying Brain Functions 2

1.1.1 Some Definitions 2

1.1.2 Sensory Functions 9

1.1.3 Motor Control 16

1.1.4 Behavioral States of Vigilance 18

1.1.5 Abnormal Mental Activities 24

1.2 From Discrete Cortical Localizations to the Concept of Unified Corticothalamic Networks 27

1.2.1 Early Attempts at Brain Localizations 27

1.2.2 Neuronal Properties Implicated in the Corticothalamic Dialogue 31

1.2.3 Fast Rhythms: An Example of Coherent Activities in Corticothalamic Networks 35

1.3 Multiple Modulatory Systems and Their Interactions 42

1.3.1 Generalized and Specific Activation 43

1.3.2 Conventional Synaptic and Diffuse (Volume) Transmission 54

1.3.3 Reciprocal Relations Among Brainstem, Diencephalic, and Forebrain Nuclei 59

Chapter 2 Evolution of Methods in Brain Studies 65

2.1 From Brain Transections to Slices and Cultures 66

2.1.1 Brain Transections, the Choice of Anesthesia, and Other Preparations 67

2.1.2 Slices and Cultures 71

2.2 Studies on Neuronal Structure 74

2.2.1 Some Developments of the Golgi Method 75

2.2.2 Anterograde and Retrograde Tracing Techniques 76

2.2.3 Chemical Anatomy 79

2.2.4 Intracellular Staining of Functionally Characterized Neurons 81

2.3 Recordings of Brain Electrical Activity 85

2.3.1 Electroencephalography, Magnetoencephalography, and Evoked Potentials 85

2.3.2 Extracellular Recordings 92

2.3.3 Intracellular Recordings 97

2.4 Noninvasive Imaging Methods 101

Chapter 3 Similar and Contrasting Results from Studies in the Intact and Sliced Brain 103

3.1 Seminal Findings in Brain Slices and Their Relation to Studies in the Intact Brain 104

3.1.1 Thalamus 104

3.1.2 Neocortex 109

3.1.3 Brainstem Cholinergic Nuclei 119

3.2 Dissimilar Data Obtained in the Sliced Brain and in Intact-Brain Preparations 122

3.2.1 Morphological Differences 122

3.2.2 Resting Properties and Firing Patterns of Cortical Neurons in Slices and Intact-Cortex Preparation 129

3.2.3 Functional Aspects of Thalamic Neurons Studied in Vivo and In Vitro 153

3.2.4 Normal and Pathological Oscillatory Activities in the Sliced and Intact Brain 166

Chapter 4 Building Blocks of Synaptic Networks Underlying Normal and Paroxysmal States 191

4.1 Neuronal Properties and Synaptic Networks of the Neocortex, Thalamus, and Related Subsystems 191

4.1.1 Neocortex 191

4.1.2 Thalamus 203

4.1.3 Rhinal Cortices and Amygdala Nuclear Complex 207

4.2 Emergent Functions of Normal Corticothalamic Networks: Oscillatory Properties and Short-Term Plasticity 210

4.2.1 Inhibitory Processes and Synchronization 210

4.2.2 Coalescence of Different Oscillatory Types in Corticothalamic Networks 213

4.2.3 Intracellular Activities of Neocortical Neurons During Natural Wake and Sleep States 241

4.2.4 Short-Term Plasticity Following Oscillations in the Thalamus and Neocortex 252

4.3 Paroxysmal States in Corticothalamic Networks 271

Chapter 5 Of Neurons and Consciousness 291.

Notes:

"A Bradford book."

Includes bibliographical references (pages 297-362) and index.

Description based on print version record.

Other Format:

Print version: Steriade, Mircea. Intact and sliced brain.

ISBN:

9780262284318

0262284316

Access Restriction:

Restricted for use by site license.