Neurobiological basis of migraine / edited by Turgay Dalkara, Michael A. Moskowitz.

Format:

Book

Contributor:

Dalkara, Turgay, editor.

Moskowitz, Michael A., editor.

ProQuest ebook central.

Dr. William McDowell Mastin Fund.

Language:

English

Subjects (All):

Migraine.

Migraine Disorders.

Brain--physiopathology.

Models, Neurological.

Medical Subjects:

Migraine Disorders.

Brain--physiopathology.

Models, Neurological.

Physical Description:

1 online resource (xxiv, 397 pages.)

Place of Publication:

Hoboken, NJ : John Wiley & Sons Inc., [2017]

System Details:

text file

Summary:

A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines, Published with the New York Academy of Sciences, Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the world. Written for researchers and clinicians alike, the book features edited contributions from distinguished experts in the field, taking a focused, yet wide-ranging approach to the subject. It begins by exploring the pathways and networks mediating migraine headaches, their underlying physiological mechanisms, characteristics of visceral pain, and the concept of dural neurogenic inflammation. From there the authors delve into the mechanisms sustaining the head pain and photophobia associated with migraines, and they review the pharmacology of newly discovered migraine treatments. These basic chapters are followed by clinical and genetic studies linking to key issues, including cortical spreading depression, ion channels, transporters, and epilepsy. Reviews the latest advances in our understanding of the neurobiological basis of migraine, Translates important research findings from around the globe into novel treatment strategies currently being investigated, Provides researchers and clinicians with a deep understanding of the primary mechanisms of migraine from migraine modeling to clinical applications, Includes contributions by many of the most respected researchers in the field, Discusses exciting recent developments in migraine mutations and their role in CSD, as well as the role of CSD in aura and trigeminal activation, Timely, comprehensive, and authoritative, Neurobiological Basis of Migraine is an indispensable working resource for clinicians and migraine, headache, and pain researchers, including neurobiologists, neuropharmacologists, neurologists, and vascular neurobiologists, as well as graduate students in those fields who are involved in researching migraine headaches. Book jacket.

Contents:

Functional anatomy of trigeminaovascular pain / Karl Messlinger and Mária Dux

Physiology of the meningeal sensory pathway / Andrew Strassman and Agustin Melo-Carrillo

Meningeal afferent ion channels and their role in migraine / Gregory Dussor

Functional architecture of central pain pathways : focus on the trigeminovascular system / Rodrigo Noseda and Luis Villanueva

Visceral pain / Michael S. Gold and G.F. Gebhart

Meningeal neurogenic inflammation and dural mast cells in migraine pain / Dan Levy

Sensitization and photophobia in migraine / Aaron Schain and Rami Burstein

Central circuits promoting chronification of migraine / Christopher W. Atcherley, Kelsey Nation, Milena De Felice, Jennifer Y. Xie, Michael H. Ossipov, David W. Dodick and Frank Porreca

Triptans to calcitonin gene-related peptide modulators : small molecules to antibodies

the evolution of a new migraine drug class / Richard J Hargreaves

Lessons learned from CGRP mutant mice / Levi P. Sowers, Annie E. Tye and Andrew F. Russo

The clinical characteristics of migraine / F. Michael Cutrer, Ryan Smith and David W. Dodick

The premonitory phase of migraine / Michele Viana and Peter J Goadsby

The genetic borderland of migraine and epilepsy / Isamu Aiba and Jeffrey Noebels

Genetics of monogenic and complex migraine / Else A. Tolner, Else Eising, Gisela M. Terwindt, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg

Lessons from familial hemiplegic migraine and cortical spreading depression / Daniella Pietrobon

From cortical spreading depression to trigeminovascular activation in migraine / Turgay Dalkara and Michael A. Moskowitz

Mathematical modeling of human cortical spreading depression / Markus A. Dahlem

Tools for high resolution in vivo imaging of cellular and molecular mechanisms in cortical spreading depression and spreading depolarization / Kivilcim Kilic, Hana Uhlirova, Peifang Tian, Payam A. Saisan, Mohammad Abbas Yaseen, Jonghwan Lee, Sergei A. Vinogradov, David A. Boas, Sava Sakadzic, Anna Devor

Animal models of migraine aura / Shih-Pin Chen, Jeremy Theriot, Cenk Ayata and KC Brennan

Human models of migraine / Jakob Moller Hansen and Messoud Ashina

Imaging pain and headache / Duncan J. Hodkinson, Sophie L. Wilcox, and David Borsook.

Notes:

Includes bibliographical references and index.

Electronic reproduction. Ann Arbor, MI Available via World Wide Web.

Description based on print version record.

Local Notes:

Acquired for the Penn Libraries with assistance from the Dr. William McDowell Mastin Fund.

Other Format:

Electronic version: Neurobiological basis of migraine.

ISBN:

9781118967201

1118967208

Publisher Number:

99973283217

Access Restriction:

Restricted for use by site license.