G Protein-Coupled Receptor Kinases / edited by Vsevolod V. Gurevich, Eugenia V. Gurevich, John J.G. Tesmer.

Format:

Book

Contributor:

Gurevich, Vsevolod V., editor.

Gurevich, Eugenia V., editor.

Tesmer, John J.G., editor.

SpringerLink (Online service)

Series:

Methods in pharmacology and toxicology 1557-2153

Methods in Pharmacology and Toxicology, 1557-2153

Language:

English

Subjects (All):

Medicine.

Pharmacology.

Physical Description:

1 online resource (XI, 329 pages) : 36 illustrations, 33 illustrations in color.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Humana Press, 2016.

System Details:

text file PDF

Summary:

This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

Contents:

G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery

Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7

Visual G Protein-Coupled Receptor Kinases

Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily

"Barcode" and Differential Effects of GPCR Phosphorylation by Different GRKs

Cell-Type Specific GRK2 Interactomes: Physiopathological Implications

Differential Regulation of IGF-1 and Insulin Signaling by GRKs

Differential Control of Potassium Channel Activity by GRK2

Critical Role of GRK2 in the Prevention of Chronic Pain

Roles of GRK Dysfunction in Alzheimer's Pathogenesis

Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases

G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation

GRK Roles in C. elegans

Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway.

Other Format:

Printed edition:

ISBN:

9781493937981

Access Restriction:

Restricted for use by site license.