Metals in the Brain : Measurement and Imaging / edited by Anthony R. White.

Format:

Book

Contributor:

White, Anthony R., Dr., editor.

SpringerLink (Online service)

Series:

Neuromethods 0893-2336 ; 124.

Neuromethods, 0893-2336 ; 124

Language:

English

Subjects (All):

Medicine.

Neurosciences.

Physical Description:

1 online resource (XII, 270 pages) : 58 illustrations, 31 illustrations in color.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Humana Press, 2017.

System Details:

text file PDF

Summary:

This volume explores methods used to examine metal levels and distribution in brain tissue or brain-derived cells. The chapters in this book discuss the use of fluorescent metal probes, synchrotron-based X-ray microscopy, ICP-MS, laser ablation-ICP-MS, laser-based tissue microdissection, MRI image analysis, fractionation of cell tissue samples for metal analysis, and metal treatment of cells. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Practical and cutting-edge, Metals in the Brain: Measurement and Imaging is a valuable resource for researchers in the rapidly growing area of neuroscience research.

Contents:

Introduction and Overview

X-Ray Microscopy for Detection of Metals in the Brain

Imaging Metals in the Brain by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry

Fluorescent Probes for the Analysis of Labile Metals in the Brain Cells

Probing Biological Trace Metals with Fluorescent Indicators

Microdissection of Brain Tissue to Resolve the Comparative Dissemination of Metal Concentrations in Neurodegenerative Diseases, Focusing on Manganese

Analysis of Trace Elements and Metalloproteins in Fractionated Human Brain Samples using Size Exclusion Inductively Couples Mass Spectrometry

Size-Fractionation of Metal Species from Serum Samples for Studying Element Biodistribution in Alzheimer's Disease

Lead Uptake and Localization in Glial Cell Cultures

Evaluating Iron Flux in the Brain

Current Methods used to Probe and Quantify Intracellular Total and Free Zn(II) Dynamics, and Subcellular Distribution in Cultured Neurons

Monitoring Intracellular Zn2+ using Fluorescent Sensors: Facts and Artifacts

Measuring Changes in Brain Manganese or Iron using Magnetic Resonance Imaging (MRI)

Treatment and Measurement of Metals in Brain Cell Cultures.

Other Format:

Printed edition:

ISBN:

9781493969180

Access Restriction:

Restricted for use by site license.