Contraceptive risk : the FDA, Depo-Provera, and the politics of experimental medicine / William Green.

Format:

Book

Author/Creator:

Green, William, 1950- author.

Series:

Biopolitics (New York, N.Y.)

Biopolitics : medicine, technoscience, and health in the 21st century

Language:

English

Subjects (All):

Contraception.

Women--Health risk assessment.

Women.

Contraceptives--Safety measures.

Contraceptives.

Contraception--history.

Medroxyprogesterone Acetate--history.

Industrial safety.

Medical Subjects:

Contraception--history.

Medroxyprogesterone Acetate--history.

Physical Description:

xiii, 322 pages ; 23 cm.

Place of Publication:

New York : New York University Press, [2017]

Summary:

"Depo-Provera is known as an injectable hormonal birth control method, but few are familiar with its dark and complicated history. Depo-Provera was tested on women since the mid-1960s without their informed consent until it was FDA-approved in 1992, but never FDA-approved as chemical castration for male sex offenders. Contraceptive risk is William Green's landmark study of Depo-Provera. Based on a fascinating combination of archival materials and interviews, the book is framed as three interconnected stories told by Judith Weisz, who chaired the FDA's Public Board of Inquiry on Depo-Provera, a scientific court; by Anne MacMurdo who brought a products liability suit against Upjohn, the drug's manufacturer, for the deleterious side effects she suffered from the drug's use; and by Roger Gauntlett, an Upjohn heir who, when he was convicted of sexual assault, refused to take a dose of his family's own medicine as a probation condition. Together these three stories of Depo-Provera's convoluted fifty year odyssey call for a paradigm shift in pharmaceutical drug development. Contraceptive risk is a thoroughly researched and engrossing approach to the scientific, political and institutional forces involved in health law and policy, as well as the multifaceted politics of measuring risk"--Back cover.

Contents:

Introduction : the odyssey of Depo-Provera

The Grady Hospital study : the corruption of contraceptive research

The twenty-five-year FDA approval controversy : cancer and the politics of acceptable risk

Contraceptive chaos : unapproved use and Upjohn v. MacMurdo

Marketing approval and litigation : osteoporosis and the realities of medical risk

Chemical castration : the John Hopkins Clinic and People v. Gauntlett

Conclusions : contraceptive drug risk failure, human dignity, and a duty to act.

Notes:

Includes bibliographical references (pages 239-303) and index.

ISBN:

9781479876990

1479876992

9781479836987

1479836982

OCLC:

961160724