Translational ADMET for drug therapy : principles, methods, and pharmaceutical applications / Souzan Yanni.

Format:

Book

Author/Creator:

Yanni, Souzan, author.

Language:

English

Subjects (All):

Pharmacokinetics.

Physical Description:

1 online resource (367 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley, 2015.

Summary:

Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations. * Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations * Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage * Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines * Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies * Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval

Contents:

""Title Page""; ""Copyright""; ""Table of Contents""; ""Contributors""; ""Preface""; ""Acknowledgement""; ""Chapter 1: Translational Concept and Determination of Drug Absorption""; ""1.1 Drug Absorption, Mechanism, and Its Impact on Drug Bioavailability, Drug Disposition, and Drug Safety""; ""1.2 Effect of Physiochemical Property-Related Factors on Drug Absorption""; ""1.3 Effect of GI-Physiological Factors and Patient Condition on Drug Absorption""; ""1.4 Effect of food and formulation on drug absorption""; ""1.5 Translational Approaches to Determine Drug Absorption in Clinical Studies""

""References""""Chapter 2: Distribution: Principle, Methods, and Applications""; ""2.1 Introduction: Drug Distribution in Relation to Drug Disposition in Humans""; ""2.2 Influence of Drug-Related Physiochemical Factors on Drug Distribution""; ""2.3 Influence of Physiological Factors on Drug Distribution""; ""2.4 Plasma Protein Binding""; ""2.5 Role of Drug Transporters in Drug Distribution""; ""2.6 Translational Methods and Approaches in Determining Drug Distribution""; ""2.7 Impact of Drug Distribution in Drug Disposition DDI in Clinic""; ""References""

""Chapter 3: Metabolism: Principle, Methods, and Applications""""3.1 Introduction: An Overview on Drug Metabolism in Relation to Clearance-Mediated by Phase I, Phase II, and Phase III Drug-Metabolizing Enzymes""; ""3.2 Common Phase I, II, and III Drug Metabolism Reactions""; ""3.3 Metabolic Clearance as a Critical Factor Influencing Drug Action and Safety""; ""3.4 Species Differences in Drug Metabolism""; ""3.5 Translational Technologies and Methodologies and Regulatory Recommendation for Drug Metabolism""; ""References""

""Chapter 4: Excretion: Principle, Methods, and Applications for Better Therapy""""4.1 Outline of Drug Excretion and Mechanisms""; ""4.2 Excretion of Drugs in Humans as Function of Drug Transporters""; ""4.3 Translational Tools to Determine the Biliary and Renal Clearance""; ""4.4 Impairment of Drug Elimination""; ""References""; ""Chapter 5: Drug-Drug Interaction: From Bench to Drug Label""; ""5.1 Introduction: The Impact of Drug-Drug Interaction on Drug Disposition and Drug Safety""; ""5.2 DDIs Implicated with Drug-Metabolizing Enzymes (DMEs) and Drug Metabolism""

""5.3 Incidence of DDI Due to Drug Transporters""""5.4 Clinical DDI""; ""5.5 Conclusion""; ""References""; ""Chapter 6: General Toxicology: Principle, Methods, and Applications1""; ""6.1 Introduction: The History of Toxicology""; ""6.2 The Multifaceted Field of Toxicology""; ""6.3 Characteristics of Toxicants, Toxins, and Exposures""; ""6.4 Adverse Drug Reactions: Idiosyncratic and Drug-Induced Liver Injury (DILI)""; ""6.5 In Vitro Determination of Reactive Metabolite Formation, Oxidative Stress, Mitochondrial Damage, and Nephrotoxicity""

""6.6 Present and Future for Assessing Toxicity in Drug Discovery and Development""

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781118838419

1118838416

9781118838327

1118838327

OCLC:

905450321