The challenges of antibiotic resistance in the development of new therapeutics / Oliveira Manuela, Isa D. Serrano, editors ; contributors Amelia Fernandes [and twenty five others].

Format:

Book

Contributor:

Manuela, Oliveira, editor.

Serrano, Isa D., editor.

Fernandes, Amelia, contributor.

Series:

Frontiers in Antimicrobial Agents

Frontiers in Antimicrobial Agents, 2452-2589 ; Volume 1

Language:

English

Subjects (All):

Drug resistance in microorganisms.

Physical Description:

1 online resource (279 p.)

Edition:

1st ed.

Place of Publication:

Sharjah, United Arab Emirates : Bentham Science Publishers Ltd., [2015]

Summary:

The addition of only two novel classes of antibiotics to fight drug resistant microorganisms in the clinic over the past three decades means that the quest for new molecules that are effective against the threat of drug resistance is now a significant iss

Contents:

CONTENTS; FOREWORD ; PREFACE ; List of Contributors ; Introduction ; INTRODUCTION; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Bacteriophages as Antibacterial Agents: Why are We Facing an Antibiotic Crisis and How Could Bacteriophages be of Help? ; 1. INTRODUCTION; 2. WHY ARE WE FACING AN ANTIBIOTIC (AB) CRISIS? ; 3. HOW TO RESOLVE THIS ANTIBIOTIC CRISIS? ; 4. BACTERIOPHAGES OR IN SHORT 'PHAGES'; 5. BACTERIOPHAGE THERAPY OR PHAGE THERAPY; 6. EXPERIMENTAL PHAGE THERAPY; 7. SAFETY ISSUES; 8. IN FACT WE LIVE IN AN "OCEAN" OF BACTERIOPHAGES; 9. SAFETY REQUIREMENTS FOR PHAGE THERAPY

10. THE POTENTIAL ADVANTAGES OF PHAGE THERAPY VERSUS ANTIBIOTICS11. PHAGE THERAPY IN PUBLIC HEALTH; 12. WHY PHAGE THERAPY IS NOT YET IMPLEMENTED?; CONCLUSIONS AND PERSPECTIVES; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Antimicrobial Peptides ; INTRODUCTION; 1. WHAT ARE ANTIMICROBIAL PEPTIDES (AMPS); 1.1. Mode of Action; 1.2. Immune System; 1.3. Resistance; 2. CHRONOLOGY OF AMPS DISCOVERY - A BRIEF HISTORY; 2.1. Classification of AMPs; 2.1.1. Biological Source; 2.1.2. Biological Functions; 2.1.3. Biosynthesis; 2.1.4. Molecular Properties; 2.1.5. Molecular Targets

2.1.6. Three-Dimensional (3D) Structure2.2. Currently Active AMPs Databases; 3. THERAPEUTIC APPLICATIONS OF AMPS; 3.1. Anticancer AMPs; 3.2. Antiviral AMPs; 3.3. Anti-parasitic AMPs; 3.4. New Generation of AMPs; CONCLUDING REMARKS; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Probiotics: Ways of Action and Beneficial Effects ; 1. INTRODUCTION; 2. SELECTION OF PROBIOTICS; 3. COMMERCIALLY IMPORTANT PROBIOTICS; 4. MECHANISMS OF ACTION OF PROBIOTICS; 4.1. Immunomodulation; 4.2. Direct Effects on Other Microorganisms; 5. BENEFICIAL HEALTH EFFECTS OF PROBIOTICS

5.1. Alleviation of Lactose Intolerance5.2. Effect on Helicobacter Pylori Eradication ; 5.3. Anti-carcinogenic Effect; 5.4. Cholesterol-lowering Effects; 5.5. Allergy and Atopic Dermatitis; 5.6. Inflammatory Diseases and Bowel Syndromes ; CONCLUSION; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Immunotherapy ; 1. BACTERIAL INFECTIVITY, IMMUNE RESPONSE AND MULTIRESISTANT INFECTIONS : NEW PERSPECTIVES; 1.1. Introduction; 1.2. Host Resistance; 1.3. Bacterial Strategies for Evading, Surviving Host Defense Systems and Create Infection; 2. IMMUNOTHERAPY; 2.1. Introduction

2.2. Applications of Immunotherapy2.3. Passive Immunotherapy; 2.4. Passive Immunotherapy: Antibodies ; 2.5. Passive Immunotherapy: Adoptive T-cell Transfer; 2.6. Passive Immunotherapy: Immunomodulators; 2.7. Growth Factors; 2.7.1. Filgastrim ; 2.7.2. Sargramostim ; 2.7.3. Erythropoietin (EPO) ; 2.7.4. Insulin-like Growth Factor-1 (IGF-1); 2.8. Interleukins; 2.8.1. Interleukin 2; 2.8.2. Interleukin-8; 2.9. Interferons; 2.9.1. Human Interferon Alpha (HuIFN- α); 2.9.2. Recombinant-Feline Interferon Omega (rFeIFN- ω) ; 2.10. Nonspecific Immunostimulants; 2.10.1. Staphylococcal Protein A (SPA)

2.10.2. Propionibacterium Acnes

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed August 2, 2016).

ISBN:

1-68108-140-7

OCLC:

953657042