Movement disorders : genetics and models / edited by Mark S. LeDoux.

Format:

Book

Contributor:

LeDoux, Mark, editor.

Language:

English

Subjects (All):

Movement disorders--Genetic aspects.

Movement disorders.

Physical Description:

1 online resource (1320 p.)

Edition:

2nd ed.

Place of Publication:

London : Elsevier, 2015.

Language Note:

English

Summary:

The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorde

Contents:

Front Cover; Movement Disorders; Contents; Foreword; Preface; Contributors; Section I - SCIENTIFIC FOUNDATIONS; Chapter 1 - Taxonomy and Clinical Features of Movement Disorders; 1.1 INTRODUCTION; 1.2 PARKINSON DISEASE; 1.3 ESSENTIAL TREMOR; 1.4 HUNTINGTON DISEASE AND OTHER CHOREIFORM DISORDERS; 1.5 DYSTONIA; 1.6 WILSON DISEASE; 1.7 MYOCLONUS; 1.8 GILLES DE LA TOURETTE SYNDROME; 1.9 DRUG-INDUCED MOVEMENT DISORDERS; 1.10 HEMIBALLISM; 1.11 SUMMARY; References; Chapter 2 - Modeling Disorders of Movement; 2.1 SCIENTIFIC APPLICATION OF ANIMAL MODELS; 2.2 CHOICE OF THE APPROPRIATE ANIMAL MODEL

2.3 EXPERIMENTAL APPROACHES2.4 DISORDER-SPECIFIC ANIMAL MODELS; Acknowledgments; References; Chapter 3 - New Transgenic Technologies; 3.1 GENOME MODIFICATION; 3.2 INDUCIBLE TRANSGENES AND CONDITIONAL ALLELES; 3.3 APPLICATIONS OF TRANSGENIC TECHNOLOGY AND TRANSGENE DESIGN; 3.4 NEW TECHNOLOGIES: THE ADVENT OF NUCLEASES; 3.5 AVOIDING EXPERIMENTAL SNARES IN ANIMAL MODEL RESEARCH; 3.6 FUTURE PROSPECTS; References; Further Reading; Chapter 4 - Assessment of Movement Disorders in Rodents; 4.1 INTRODUCTION; 4.2 BASIC CONCEPTS OF ANIMAL MODELING; 4.3 SPECIFIC TESTS FOR MOTOR ABNORMALITIES

4.4 GLOBAL STRATEGIES FOR ASSESSING MOVEMENT DISORDERS4.5 SUGGESTED TEST BATTERIES FOR SPECIFIC MOVEMENT DISORDERS; 4.6 SUMMARY; Acknowledgments; References; Chapter 5 - Drosophila; 5.1 INTRODUCTION: A HISTORICAL PERSPECTIVE ON FLIES AND GENETIC DISEASE RESEARCH; 5.2 BASICS OF GENETIC ANALYSIS; 5.3 GENES, GENOME, AND HOMOLOGIES; 5.4 NERVOUS SYSTEM ORGANIZATION; 5.5 DETECTING MOVEMENT ABNORMALITIES; 5.6 GENETIC TOOLS OF THE TRADE; 5.7 APPLICATIONS OF THE DROSOPHILA MODEL IN MOVEMENT DISORDER RESEARCH; 5.8 PROSPECTS FOR THE FUTURE; References

Chapter 6 - Use of Caenorhabditis elegans to Model Human Movement Disorders6.1 CAENORHABDITIS ELEGANS: WHY THE WORM?; 6.2 CAENORHABDITIS ELEGANS WEB-BASED RESOURCES; 6.3 THE C. ELEGANS NERVOUS SYSTEM; 6.4 DETECTION OF MOVEMENT ABNORMALITIES; 6.5 TOOLS OF THE WORM TRADE; 6.6 AS THE WORM TURNS: APPLICATION OF C. ELEGANS TO MOVEMENT DISORDERS RESEARCH; 6.7 DRUG SCREENING; 6.8 CONCLUDING REMARKS; Acknowledgments; References; Chapter 7 - Zebrafish; 7.1 INTRODUCTION; 7.2 WHY ZEBRAFISH MODELS ARE USEFUL: SCREENS, IN VIVO IMAGING, AND GENETIC TOOLS

7.3 ZEBRAFISH GENES, CELLS, AND CIRCUITS RELEVANT TO STUDYING HUMAN MOTOR SYSTEM DISEASES7.4 ZEBRAFISH GENETIC METHODS: KNOCKOUTS AND TRANSGENIC LINES; 7.5 NEUROBEHAVIORAL TESTING IN ZEBRAFISH; 7.6 CHEMICAL SCREENING; 7.7 CONCLUSIONS; References; Chapter 8 - Techniques for Motor Assessment in Rodents; 8.1 INTRODUCTION; 8.2 MOTOR COORDINATION AND BALANCE; 8.3 LOCOMOTOR ACTIVITY; 8.4 FINE MOTOR SKILLS; 8.5 AKINESIA AND MUSCULAR STRENGTH; 8.6 CONCLUSIONS; References; Chapter 9 - Induced Pluripotent Stem Cells (iPSCs) to Study and Treat Movement Disorders; 9.1 BACKGROUND

9.2 MODELING MOVEMENT DISORDERS USING IPSCS

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed October 15, 2014).

ISBN:

0-12-405516-8