Progress in molecular biology and translational science. Volume one hundred and twenty nine, The molecular basis of viral infection / edited by P. J. Klasse ; contributors, Kristine Niss Arfelt [and thirty two others].

Format:

Book

Contributor:

Klasse, P. J., editor.

Arfelt, Kristine Niss, contributor.

Series:

Progress in molecular biology and translational science ; Volume 129.

Progress in Molecular Biology and Translational Science, 1877-1173 ; Volume 129

Language:

English

Subjects (All):

Virus diseases.

Physical Description:

1 online resource (468 p.)

Place of Publication:

Waltham, Massachusetts : Academic Press, 2015.

Language Note:

English

Summary:

Virology is in a sense both one of the most important precursors and one of the most significant beneficiaries of structural and cellular molecular biology. Numerous breakthroughs in our understanding of the molecular interactions of viruses with host cells are ready for translation into medically important applications such as the prevention and treatment of viral infections. This book collects a wide variety of examples of frontline research into molecular aspects of viral infections from virological, immunological, cell- and molecular-biological, structural, and theoretical perspectives.Con

Contents:

Front Cover; The Molecular Basis of Viral Infection; Copyright; Contents; Contributors; Preface; References; Chapter 1: Unity in Diversity: Shared Mechanism of Entry Among Paramyxoviruses; 1. Introduction to Paramyxoviruses; 1.1. Classification and medical significance; 1.2. Structure; 1.3. Viral entry and life cycle; 2. Structure and Function of the Paramyxovirus Glycoproteins; 2.1. The receptor-binding protein; 2.2. The fusion protein; 3. Proposed Mechanisms of Receptor-Binding Protein and Fusion Protein Interactions

3.1. The globular heads of the receptor-binding protein selectively engage specific cellular receptors3.2. The stalk domain of the receptor-binding protein interacts with and activates F; 3.3. The role of the receptor-binding protein before receptor engagement; 3.4. The receptor-binding protein transmits a triggering signal to the fusion protein upon receptor engagement; 3.5. The fusion protein inserts its hydrophobic fusion peptide into the target membrane leading to the formation of the f...; 3.6. The interaction between HN/H/G and F modulates infection in the natural host; 4. Conclusions

AcknowledgmentsReferences; Chapter 2: Alphavirus Entry into Host Cells; 1. Introduction; 1.1. Alphaviruses; 1.2. Alphavirus life cycle; 1.3. Alphavirus structure; 2. Alphavirus Interaction with Host Cells; 2.1. Role of attachment factors and receptors; 2.1.1. Putative receptors; 2.2. Routes for enveloped virus internalization; 2.2.1. Endocytic routes; 2.2.2. Nonendocytic routes; 2.3. Conformational changes during entry; 3. Measuring Viral Entry; 3.1. Direct observations by electron microscopy; 3.2. Role of membrane models in studies of virus entry

3.3. Role of inhibitors in studies of virus entry4. Alphavirus Genome Delivery; 4.1. Role of membrane fusion; 4.2. Role of low pH; 4.3. Role of pores in the cell membrane; 5. Alphavirus Entry in the Absence of Membrane Fusion; 5.1. A direct assay for entry at the plasma membrane; 5.2. The role of temperature in the process of infection; 5.3. The role time in the process of infection; 5.4. The role of membrane potential; 5.5. Similarities with other viruses; 5.6. Implications of a new model for entry; 6. Challenges and Perspectives; Acknowledgments; References

Chapter 3: The Mechanism of HCV Entry into Host Cells1. Introduction; 2. The Viral Particle Organization and Composition: A Fundamental Key to Decrypt Virus Entry; 3. Early Steps of Virus Entry; 3.1. Viral particle capture; 3.1.1. The heparan sulfate proteoglycans; 3.1.2. The LDL-r; 3.1.3. The scavenger receptor B-I; 3.2. Early particle rearrangements; 4. Receptor Binding and Clustering; 4.1. E1E2 glycoproteins: Viral mediator of particle binding; 4.1.1. Heterodimerization; 4.1.2. Glycosylation; 4.1.3. Envelope glycoproteins and virus morphogenesis; 4.1.4. Structure

4.1.5. E2 functions during virus binding

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed January 27, 2015).

ISBN:

9780128025871

0128025875

9780128024614

0128024615