Advances in Cancer Research. Volume 127.

Format:

Book

Author/Creator:

Tew, Kenneth D.

Contributor:

Fisher, Paul B.

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Neoplasms, Experimental.

Local Subjects:

Cancer--Research.

Cancer.

Neoplasms, Experimental.

Physical Description:

1 online resource (345 p.)

Place of Publication:

Burlington : Elsevier Science, 2015.

Summary:

<i>Advances in Cancer Research</i> provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including taxane-anti-androgens cross-resistance in advanced prostate cancer and proteasome inhibitors in the treatment of multiple myeloma.<br><br><ul><li>Provides information on cancer research</li><li>Outstanding and original reviews</li><li>Suitable for researchers and students</li></ul>

Contents:

Front Cover; Advances in Cancer Research; Copyright; Contents; Contributors; Chapter One: Unravelling the Complexity and Functions of MTA Coregulators in Human Cancer; 1. Introduction; 2. Domain Architectures of MTA Proteins; 3. Regulation of Gene Expression by MTA Proteins; 3.1. NuRD Corepressor Complexes; 3.2. Nucleosome Remodeling Factor Coactivator Complexes; 4. Subcellular Localization of MTA Proteins; 5. Upstream Regulators of MTA Gene Products in Cancer; 5.1. Transcription Factors and Coregulators; 5.2. MicroRNAs; 5.3. Growth Factors and Receptors; 5.4. Hormone and Hormone Receptors

5.5. Enzymes and Protein Kinases5.6. Cell Stressors; 6. Downstream Effectors of MTA Proteins in Cancer; 6.1. Transcriptional Targets of MTA Proteins; 6.2. Nontranscription Targets of MTA Proteins; 7. Expression and Clinical Significance of MTA Proteins in Cancer; 7.1. Head and Neck Cancer; 7.2. Digestive System Cancer; 7.3. Respiratory System Cancer; 7.4. Hormone-Related and Reproductive System Cancer; 8. Therapeutic Targeting of MTA Family Members; 9. Conclusions and Prospective; Acknowledgments; References

Chapter Two: Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer...1. Background on mda-9/Syntenin; 2. Publicly Available Cancer Genomic Datasets; 3. Specific Datasets Examined for mda-9 Analysis and the Analytical Approaches Employed; 3.1. Publicly Available Genomic Datasets; 3.2. Analytical Tools; 4. The Patterns of mda-9 Expression During Cancer Progression and Their Clinical Implications in Different Cancer Types; 4.1. Glioma; 4.2. Melanoma, Prostate Cancer, Liver Hepatocellular Carcinoma, and Kidney Renal Papillary Carcinoma

4.3. mda-9 Expression in Metastasis Samples5. mda-9 Expression Correlates with Both Gene Copy Number and the Methylation Status of cg1719774; 5.1. mda-9 RNA Expression Generated Illumina HiSeq Data; 5.2. mda-9 Copy Number as Determined by Affymetrix SNP Array; 5.3. mda-9 CpG Sites Interrogated in Illumina 450K Array; 5.4. Which Among the Two CpG Sites Influence mda-9 Expression?; 5.5. Glioma; 5.6. Melanoma, Prostate Cancer, Liver Hepatocellular Carcinoma, and Kidney Renal Papillary Carcinoma; 5.7. Combination of the Six Cancer Datasets; 6. mda-9 is Highly Expressed in Melanoma

6.1. mda-9 RNA Expression Across all Cancer Types (PANCAN Dataset)6.2. MDA-9 Protein Expression Across all Cancer Types (The Human Protein Atlas); 7. Hypomethylation at cg1719774 is Associated with Histone Modifications Indicative of Higher Transcriptional Activity; 7.1. Information from the ENCODE Project; 7.2. How CpG Methylation is Associated with Differential Binding of Modified Histones; 8. Predicting Genes and Pathways Associated with mda-9 Dysregulation in Glioma; 8.1. Comparing mda-9-High and mda-9-Low Subtypes of Glioma

8.2. Genes that are Most Highly Dysregulated in mda-9-High Glioma

Notes:

Description based upon print version of record.

ISBN:

9780128029428

0128029420

9780128029206

012802920X