Advances in immunology. Volume one hundred and twenty five / edited by Frederick W. Alt ; contributors, Takeshi Egawa [and eight others].

Format:

Book

Contributor:

Alt, Frederick W., editor.

Egawa, Takeshi, contributor.

Series:

Advances in immunology ; Volume 125.

Advances in Immunology, 0065-2776 ; Volume 125

Language:

English

Subjects (All):

Immunology.

Physical Description:

1 online resource (216 p.)

Place of Publication:

Waltham, Massachusetts : Academic Press, 2015.

Language Note:

English

Summary:

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field

Contents:

Front Cover; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: Regulation of CD4 and CD8 Coreceptor Expression and CD4 Versus CD8 Lineage Decisions; 1. Introduction; 2. CD4 and CD8 Coreceptors and Thymocyte Selection; 2.1. Molecular timers defining the duration of positive selection signals; 2.2. Quencher of free Lck to assure MHC restriction of TCR; 3. Cis-Regulatory Elements for Genes Encoding CD4 and CD8 Coreceptors; 3.1. Regulatory elements for Cd4; 3.2. Regulatory elements or Cd8a/Cd8b1

4. Transcription Factors Regulating CD4 and CD8 Expression and Lineage Choice in the Thymus4.1. Runx proteins and Thpok; 4.2. AP4; 4.3. Mazr; 4.4. Other factors; 5. Regulation of CD4 and CD8 in Mature T Cells; 5.1. Epigenetic regulation of Cd4; 5.2. Plasticity of CD4+ intraepithelial T cells; 6. Cytokine Receptor Signals and CD4/CD8 Lineage Commitment; 6.1. The role of IL-7R signals in the kinetic signaling model; 6.2. Analysis of mice lacking IL-7Rα or IL-2Rγ; 7. Concluding Remarks; Acknowledgments; References

Chapter Two: Mast Cells Integrated Actions with Eosinophils and Fibroblasts in Allergic Inflammation: Implications for Th...1. Introduction; 2. Mast Cells and Eosinophils in Allergic Inflammation; 3. Mast Cell Eosinophil Cross-Talk: The Allergic Effector Unit; 3.1. Soluble interactions; 3.2. Physical interactions; 4. Fibroblasts from Repair to Fibrosis in Allergic Inflammation; 5. Mast Cells and Fibroblasts: Bidirectional Interactions; 6. Eosinophls and Fibroblasts: Bidirectional Interactions

7. Therapeutic Implications of Mast Cells, Eosinophils, and Fibroblasts Cross Talks for Allergic Inflammation8. Future Drugs; 9. Conclusions; Acknowledgments; References; Chapter Three: Positive-Selection-Inducing Self-Peptides Displayed by Cortical Thymic Epithelial Cells; 1. Introduction; 2. Characterization of Positive-Selection-Inducing Peptides; 2.1. TCR affinity of selecting peptide-MHC complexes; 2.2. Identification of selecting peptides by mass spectrometry; 2.3. Selecting peptides affect T cell responsiveness; 2.4. Single-peptide experiments

3. Antigen Processing in Cortical Thymic Epithelial Cells3.1. Cortical thymic epithelial cells; 3.2. Thymoproteasome; 3.3. Cathepsin L and thymus-specific serine protease; 3.4. Autophagy; 4. Concluding Remarks; Acknowledgment; References; Chapter Four: Group 2 Innate Lymphoid Cells in the Regulation of Immune Responses; 1. Introduction; 2. Meet the Family; 3. Drawing Parallels Between ILC Cells and T Cells; 4. Human and Murine ILC2 Cell Phenotypes; 5. ILC2 Cell Development; 6. The Cytokine Factory; 6.1. IL-13; 6.2. IL-5; 6.3. IL-4; 6.4. IL-9; 6.5. Amphiregulin and IL-6

7. Sensing of the Environment by ILC2 Cells

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed January 27, 2015).

ISBN:

0-12-802431-3

0-12-802243-4