The flaviviruses : pathogenesis and immunity / edited by Thomas Chambers ... [et al.].

Format:

Book

Contributor:

Chambers, Thomas M.

Series:

Advances in virus research ; 60.

Advances in virus research ; 60

Language:

English

Subjects (All):

Flaviviruses.

Virus diseases--Immunological aspects.

Virus diseases.

Physical Description:

1 online resource (520 p.)

xiv, 486 p. il. (algunas en color) 24 cm

Place of Publication:

Oxford : Academic, 2004.

Language Note:

English

Summary:

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts.<b

Contents:

Front Cover; Advances in Virus Research; Copyright Page; Contents; Chapter 1. Molecular Determinants of Virulence: The Structural and Functional Basis for Flavivirus Attenuation; I. Introduction.; II. Morphology and Genome Structure.; III. Molecular Determinants of Virulence; IV. Conclusion; References; Chapter 2. Genetic Resistance to Flaviviruses; I. Introduction; II. Initial Discoveries of Genetic Resistance to Flaviviruses in Mice; III. Flavivirus Genetic Resistance in Wild Mice; IV. Development of Congenic Flavivirus-Resistant and -Susceptible Mouse Strains

V. Virus Specificity of the Flvr Phenotype in MiceVI. Characteristics of the Flvr Phenotype; VII. Other Characteristics of Resistant C3H.PRI-Flvr Mice; VIII. Mapping the Flv Gene to Chromosome 5; IX. Analysis of Other Known Genes that Map Close to the Flv Locus on Chromosome 5; X. Positional Cloning of the Flv Gene; XI. Identification of the Flv Gene as Oas1b; XII. Possible Mechanism of Action of the Resistant Allele of the Oas1b Gene; XIII. Conclusions; References; Chapter 3. Immunobiology of Mosquito-Borne Encephalitic Flaviviruses; I. Introduction; II. Innate Immune Responses

III. Adaptive Immune ResponseIV. Virus-Host Interplay in Immunity and Pathogenesis; References; Chapter 4. Immune Modulation by Flaviviruses; I. Introduction; II. Strategies for Virus Survival in the Immune-Competent Host; III. Flavivirus Upregulates Cell Surface Recognition Molecules; IV. Mechanisms of Upregulation; V. Models of WNV Disease Pathogenesis; VI. The Paradox of Cell Surface Moldecule Upregulation, Immunopathology, and Virus Survival; VII. Flavivirus Modulation of Adaptive Immune Responses: A Hypothesis; VIII. Maternal Tolerance: A Model of Embryonic Implantation; IX. Conclusions

ReferencesChapter 5. Mechanisms of DengueVirus-Induced Cell Death; I. Introduction; II. Apoptosis and Necrosis; III. Molecular Machinery of Apoptosis; IV. Virus-Induced Apoptosis; V. Apoptotic Cell Death in Response to Dengue Virus Infection; VI. Concluding Remarks; References; Chapter 6. Dynamics Flavivirus Infection in Mosquitoes; I. Mosquito Vectors Associated with Flaviviruses; II. Flavivirus Infection of and Replication in the Mosquito Vector; III. Vectorial Capacity; IV. Impact of Reproductive Biology on Dynamics of Flavivirus Transmission

V. Role of the Vector in Perpetuation of Virus over Adverse Seasons and YearsVI. Genetics of Infection; VII. Vector Control; VIII. Future Directions; References.; Chapter 7. Dynamics of Infection in Tick Vectors and at the Tick-Host Interface; I. Introduction to Ticks; II. Tick-Borne Flaviviruses; III. Anatomy and Dynamics of Infection in Ticks; IV. Nonviremic Transmission; V. Population Biology of Tick-Borne Flaviviruses; VI. Tick-Borne Transmission on Immune Hosts; VII. Role of Skin in Tick-Borne Transmission; VIII. Saliva-Activated Transmission; IX. Host Modulation by Tick Saliva

X. The ''Red Herring'' Hypothesis

Notes:

Description based upon print version of record.

ISBN:

1-281-01074-X

9786611010744

0-08-049382-3

OCLC:

476067654