Epigenetics and neuroplasticity - evidence and debate / edited by Schahram Akbarian, Farah Lubin.

Format:

Book

Contributor:

Akbarian, Schahram., editor.

Lubin, Farah, editor.

Series:

Progress in molecular biology and translational science ; Volume 128.

Progress in Molecular Biology and Translational Science ; Volume 128

Language:

English

Subjects (All):

Epigenetics--History.

Epigenetics.

Epigenetics--Health aspects.

Physical Description:

1 online resource (263 p.)

Edition:

First edition.

Place of Publication:

Waltham, Massachusetts : Academic Press, 2014.

Language Note:

English

Summary:

The 'epi-(Greek for 'over', 'above')genome', with its rich cache of highly regulated, structural modifications-including DNA methylation, histone modifications and histone variants-defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this v

Contents:

Front Cover; Epigenetics and Neuroplasticity-Evidence and Debate; Copyright; Contents; Contributors; Preface; Chapter One: The Epigenetic Basis of Memory Formation and Storage; 1. Introduction to the Neurobiology of Learning and Memory; 2. Epigenetic Mechanisms of Memory Consolidation; 2.1. Histone acetylation; 2.2. Histone methylation; 2.3. Histone phosphorylation; 2.4. Histone ubiquitination and sumoylation; 2.5. DNA methylation; 2.6. Summary of epigenetic regulation of memory consolidation; 3. Epigenetic Mechanisms of Memory Reconsolidation

3.1. Histone modifications during memory reconsolidation3.2. DNA methylation during memory reconsolidation; 3.3. Epigenetic regulation of reconsolidation-dependent memory updating; 3.4. Summary of epigenetic regulation of memory reconsolidation; 4. Epigenetic Mechanisms of Memory Extinction; 5. Future Directions and Conclusions; Acknowledgments; References; Chapter Two: Epigenetics in Posttraumatic Stress Disorder; 1. Introduction; 2. Epigenetic Evidences in PTSD; 2.1. Methodological aspects and tissue specificity; 2.2. Candidate gene approach in animals and humans

2.2.1. Focus on the HPA axis genes2.2.2. Other stress-responsive genes; 2.3. Genome-wide studies in animals and humans; 3. Epigenetic Mechanisms in Gene by Environment Interactions in PTSD; 4. Conclusions; References; Chapter Three: Histone-Mediated Epigenetics in Addiction; 1. Introduction; 2. General Overview of Histone-Mediated Epigenetics; 3. Learning Processes Involved in the Development of Addiction; 3.1. Initial establishment of drug-associated memories; 3.2. Retrieval of drug-associated memories and extinction of drug-seeking behavior; 4. Histone-Mediated Epigenetic Mechanisms

4.1. Repressive histone modifications4.1.1. Methylation and phosphorylation; 4.2. Active histone modifications; 4.2.1. Methylation; 4.2.2. Acetylation; 4.2.3. Phosphorylation, ubiquitination, SUMOylation, and poly(ADP-ribosylation); 4.3. Combinatorial modifications; 5. Histone-Mediated Actions in Drug Addiction; 5.1. Methylation and addiction; 5.2. Acetylation and addiction; 5.3. Combinatorial modifications and addiction; 5.4. Summary of histone-mediated epigenetic regulation in addiction; 6. Debates and Considerations

6.1. Are histone marks causal or correlational to downstream processes and do histone modifications change the structure a ...6.2. What is the relation between memory at the cellular, organismal, and transgenerational levels?; 6.3. What theoretical processes are altered by drugs that target histone modifications during treatment of addiction?; 7. Considerations for Histone-Mediated Treatment of Addiction; Acknowledgments; References; Chapter Four: Modeling the Molecular Epigenetic Profile of Psychosis in Prenatally Stressed Mice; 1. The Epigenetic Hypothesis of Psychosis

1.1. DNA methyltransferase

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed December 12, 2014).

ISBN:

0-12-801085-1