Neural crest and placodes / edited by Paul Trainor.

Format:

Book

Contributor:

Trainor, Paul, editor.

Series:

Current topics in developmental biology ; Volume 111.

Current topics in Developmental Biology, 0070-2153 ; Volume 111

Language:

English

Subjects (All):

Neural crest.

Placodes.

Embryology.

Physical Description:

1 online resource (573 p.)

Place of Publication:

Waltham, Massachusetts ; San Diego, California : Academic Press, 2015.

Language Note:

English

Summary:

Neural Crest and Placodes provides in-depth coverage of the topic, including information on their critical role in vertebrate development, evolution, and the way defects in their development underlie a wide range of congenital disorders. It delves deep into advances made in our understanding of the mechanisms governing the formation, migration, and differentiation of these two cell populations, also discussing their integration during embryonic development. The text highlights the application of fundamental knowledge in investigating the etiology and pathogenesis of congenital disorders an

Contents:

Front Cover; Neural Crest and Placodes; Copyright; Contents; Contributors; Preface; Section A: Neural Crest Cells; Chapter 1: Neural Crest Cell Evolution: How and When Did a Neural Crest Cell Become a Neural Crest Cell; 1. Introduction; 2. Defining Neural Crest Cells; 3. Chordate Evolution and Vertebrate Origins; 4. Neural Crest Cell Origin; 5. Neural Crest Cell Evolution in Vertebrates; 6. Cranial Neural Crest Cell Gene Regulatory Network; 7. Evolution of Neural Crest Cell Gene Regulatory Networks; 8. Conclusions and Perspectives; Acknowledgments; References

Chapter 2: Resolving Time and Space Constraints During Neural Crest Formation and Delamination1. Integrating Space During NCC Induction and Specification: Roles of Cell Movements and Cadherin-Mediated Cell Sorting; 2. Coordinating NCC Delamination Timely and Spatially: Regulation of Cadherin Activity; 3. Coordinating NCC Specification and Delamination: Spatiotemporal Control of the Core EMT Regulatory Factors; 3.1. Transcriptional and translational controls of the expression of the core EMT regulatory factors; 3.2. Epigenetic control of the expression of the core EMT regulatory factors

3.3. Control of the stability and intracellular location of the core EMT regulatory factors3.4. Control of the activity of the core EMT regulatory factors; 4. Spatial Control of the Activity of the Zeb-2 Transcription Factor; 5. Future Prospects; Acknowledgments; References; Chapter 3: Extended Multipotency of Neural Crest Cells and Neural Crest-Derived Cells; 1. Introduction; 2. Postmigratory NCSC: Multipotent Cells are Maintained in the Tissues; 3. Cultured NCSC-Like Cells Originating from the Hair Follicle and Dermis; 4. Retention of Multipotency in Differentiated NCC-Derived Cells

4.1. Plasticity of NCC-derived glial cells4.2. Plasticity of glial cells plays a significant role in embryogenesis; 4.3. Plasticity of lineage-restricted melanocytes or their precursors; 5. Maintained Multipotency in Postmigrating NCC and NCC Derivatives; 5.1. Multipotency of NC-derived lineage-restricted melanoblasts; 5.2. Duration of the multipotency of NCC-derived cells after delamination from the neural tube; 6. Remarks on the Origin of Melanomas; 7. Concluding Remarks; Acknowledgments; References; Chapter 4: The Ciliary Baton: Orchestrating Neural Crest Cell Development; 1. Introduction

2. The Primary Cilium: Defining the Organelle2.1. Structure equals function; 2.2. Widespread and dynamic; 2.3. Ciliogenesis: Building the cilium; 3. The Role of Primary Cilia during NCC Ontogeny; 3.1. Primary cilia and NCC specification; 3.2. Primary cilia and NCC migration; 3.3. Primary cilia and NCC proliferation; 3.4. Primary cilia and NCC differentiation; 4. Craniofacial Phenotypes in Animal Models and Human Patients Support a Role for Primary Cilia in NCC Development; 4.1. Insights from animal models; 4.2. Human craniofacial ciliopathies

5. Beyond the Face: Trunk NCCs are Also Affected by the Loss of Primary Cilia

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed February 21, 2015).

ISBN:

0-12-407759-5

0-12-407890-7