Axon growth and regeneration Part 2 / edited by Jeffrey L. Goldberg, Ephraim F. Trakhtenberg.

Format:

Book

Contributor:

Goldberg, Jeffrey L.

Trakhtenberg, Ephraim F.

Series:

International review of neurobiology, 0074-7742 ; v. 106

Language:

English

Subjects (All):

Axons--Physiology.

Axons.

Nervous system--Growth.

Nervous system.

Nervous system--Regeneration.

Physical Description:

1 online resource (255 p.)

Edition:

1st ed.

Place of Publication:

London : Academic Press, 2012.

Language Note:

English

Summary:

Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialistLeading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comp

Contents:

Front Cover; Axon Growth and Regeneration: Part 2; Copyright; Contents; Contributors; Preface; Chapter One: Neurotrophic Factors and the Regeneration of Adult Retinal Ganglion Cell Axons; 1. Introduction; 2. Trophic Dependence of RGCs During Development; 3. Axonal Regeneration: Optic Nerve Injuries; 4. Receptors and Miscellaneous Signaling Pathways that Influence Axonal Regeneration; 5. Exogenous Neurotrophic Factors and RGC Axonal Regeneration; 6. Mode of Delivery: Recombinant Factors; 7. Neurotrophic Support and Autologous PN Grafts; 8. Nonviral Delivery Systems for Neurotrophic Factors

9. Cellular Delivery of Neurotrophic Factors10. Viral Vector Delivery of Neurotrophic Factors; 11. Combined Gene Therapy and Pharmacotherapy; 12. Administration of Neurotrophic Factors to the Axonal Growth Environment; 13. Axonal Regeneration and Optic Tract Injury Studies; 14. Indirect Actions of Neurotrophic Factors; 15. Conclusions; References; Chapter Two: Signaling Endosomes and Growth Cone Motility in Axon Regeneration; 1. Introduction; 1.1. The growth cone's vesicular matrix; 1.2. The signaling endosome hypothesis; 2. Signaling Endosome Formation; 2.1. Receptor-mediated endocytosis

2.2. Sorting and signaling2.3. Lipids and signaling; 2.4. Signaling endosomes and intra-axonal translation; 3. Signaling Endosome Signaling in the Growth Cone; 3.1. Exo- and endocytosis; 3.2. Cytoskeletal effector localization; 3.3. Adhesion formation, signaling, and turnover; 4. Nanoparticle-Mediated Signaling Endosome Manipulation; 4.1. Methodology and characterization; 4.2. Nanoparticle-mediated changes in transport; 4.3. Altering signaling endosome localization with nanoparticles alters growth cone motility; 5. Summary and Future Directions; Acknowledgments; References

Chapter Three: Intrinsic Mechanisms Regulating Axon Regeneration: An IntegrinPerspective1. Introduction; 1.1. Integrins in the nervous system; 1.2. Integrin function; 2. Integrins and Intrinsic Mechanisms of Axon Regeneration; 2.1. Conditioning lesions and cAMP; 2.2. Integrins and axon regeneration; 2.3. SOCS3 and PTEN; 3. Axonal Trafficking of Integrins and Other Membrane Proteins; 3.1. Regulated entry to the axon; 3.2. Trafficking mechanisms within the axon; 3.3. Trafficking at the growth cone; References; Chapter Four: The Role of Serotonin in Axon and Dendrite Growth; 1. Introduction

2. 5-HT Affects Neurite Growth2.1. Invertebrates and lower vertebrates; 2.2. Mammals; 3. 5-HT Receptors Subtypes Affecting Neurite Growth; 3.1. Htr1A; 3.2. Htr1B/D; 3.3. Htr2A/C; 3.4. Htr3; 3.5. Htr4/5/7; 4. Mechanisms of 5-HT Effect on Neurite Growth; 5. Discussion; 6. Conclusion; Acknowledgments; References; Chapter Five: Inflammatory Pathways in Spinal Cord Injury; 1. Introduction; 2. The Inflammatory Response After SCI; 2.1. Changes at the site of injury; 2.2. Changes in areas undergoing Wallerian degeneration; 3. Effects of Immune Cells on Secondary Damage

4. Identification of Novel Targets that Mediate Inflammatory Responses After SCI

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9781283868464

1283868466

9780124071698

0124071694

OCLC:

823390262