International review of cell and molecular biology. Volume three hundred and six / edited by Kwang W. Jeon, Department of Biochemistry, University of Tennessee, Knoxville, Tennessee.

Format:

Book

Author/Creator:

Jeon, Kwang W.

Contributor:

Jeon, Kwang W., editor.

Series:

Issn Ser.

International review of cell and molecular biology, 1937-6448 ; volume three hundred and six

Language:

English

Subjects (All):

Cells.

Molecular biology.

Cytology.

Physical Description:

1 online resource (x, 427 pages) : illustrations (some color).

Edition:

First edition.

Place of Publication:

San Diego, CA : Academic Press, 2013.

Language Note:

English

Summary:

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2011: 4.481. * Authored by some of the foremost scientists in the field * Provides up-to-date information and directions for future research * Valuable reference material for advanced undergraduates, graduate students and professional sc

Contents:

Front Cover; International Review of Cell and Molecular Biology; Copyright; Contents; Contributors; Chapter One: Cell and Molecular Biology of DNA Methyltransferase 1; 1. Introduction; 2. Positions of Genomic 5-Methyl-Cytosines and Their Significance; 2.1. Symmetric and asymmetric cytosine methylation in plants and animals; 2.2. Significance of symmetric methylation; 2.3. Holliday/Pugh and Riggs postulates for inheritance of symmetric cytosine methylation; 2.4. Experimental support for maintenance methyltransferase activity; 3. Basic Molecular Mechanisms of Maintenance Methylation

3.1. Basic chemistry of enzymatic reaction3.2. Similarities and differences in plant and animal maintenance methyltransferases; 3.2.1. Amino acid sequence alignments; 3.2.2. Preferences for hemimethylated DNA; 3.3. Structured, highly conserved regions of DNMT1 and possible functions; 3.4. Role of accessory and interacting proteins in DNMT1 methyltransferase function; 3.5. Intrinsically disordered region of DNMT1 and possible functions; 3.6. Roles of posttranslational modifications to DNMT1; 4. Genomic Methylation During Plant and Animal Life Cycles

4.1. Patterns of symmetric methylation during mouse development4.2. Developmental patterns require de novo methylation, maintenance methylation, and demethylation; 4.3. Regulation of Dnmt1 expression; 4.4. DNMT1s role in imprinting; 4.5. DNMT1 and development; 4.6. Roles for Dnmt1 in DNA repair and radiation-induced DNA damage; 5. Demethylation; 5.1. Lessons from plants-Developmental, biochemical, and genetic studies; 5.2. Evidence for active demethylation in animals; 5.3. Active versus passive demethylation; 5.4. Regulating DNMT1 and demethylation; 6. De Novo Methylation

6.1. Lessons from plants-Biochemical and genetic studies6.2. De novo methylation mechanisms in animals; 7. Concluding Remarks; References; Chapter Two: Endothelial Progenitor Cells-Potential New Avenues to Improve Neoangiogenesis and Reendothelialization; 1. Introduction; 2. Characterization of EPC; 2.1. Isolation of EPCs; 2.1.1. Hematopoietic stem cells; 2.1.2. Early EPC/circulating angiogenic cells; 2.1.3. Late EPC/ECFC; 2.1.4. Colony-forming units according to Hill et al.; 2.1.5. MC, which differentiate into ECs under the influence of cultivation factors

2.1.6. Other CPCs, termed ``side population cells ́ ́ or tissue resident progenitor cells2.1.7. Circulating mature ECs that are sheared off from vessel walls; 2.2. Phenotypical characterization; 2.3. Genetic characterization; 2.4. Effects of cytokines on EPC; 2.4.1. Vascular endothelial growth factor; 2.4.2. SDF-1; 2.4.3. G-CSF/GM-CSF; 2.4.4. TNF-alpha; 2.4.5. Other cytokines and hormones; 2.4.5.1. Erythropoietin; 2.4.5.2. Estradiol; 2.4.5.3. MIF; 2.5. Cytokines expressed by EPC; 3. EPC in Health and Disease; 3.1. EPC in the healthy; 3.2. EPC in disease; 3.2.1. Cardiovascular disease

3.2.2. Cerebral disease

Notes:

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed September 19, 2013).

"ISSN: 1937-6448."

ISBN:

9780124078437

0124078435

OCLC:

880853071