Protein modules and protein-protein interaction / edited by Joel Janin, Shoshana J. Wodak.

Format:

Book

Contributor:

Janin, Joël.

Wodak, Shoshana J.

Series:

Advances in protein chemistry ; v. 61.

Advances in protein chemistry, 0065-3233 ; v. 61

Language:

English

Subjects (All):

Proteins--Conformation.

Molecular recognition.

Physical Description:

1 online resource (343 p.)

Place of Publication:

Amsterdam ; Boston : Academic Press, c2002.

Language Note:

English

Summary:

Protein modules engage in a multitude of interactions with one another and with other cellular components, notably with DNA. These interactions are a central aspect of protein function of great relevance in the post-genomic era. This volume describes a panel of approaches for analyzing protein modules and their interactions, ranging from bioinformatics to physical chemistry, to biochemistry, with an emphasis on the structure-function relationship in protein-protein complexes involved in cellular processes including signal transduction.Key Features* Comprehensive overview of differe

Contents:

Front Cover; Advances in Protein Chemistry; Copyright Page; Contents; Chapter 1.Introduction; I. Protein Modules and Protein-Protein Interaction: Towards a Global View; Web Sites; References; Chapter 2. Structural Basis of Macromolecular Recognition; I. Introduction; II. Geomatric and Chemical Features of Macromlecular Recognition; III. Classification of Protein-Protein and Protein-DNA Complexes; IV. Energetics of Magromolecular Recognition; V. Computational Approaches for Predicting and Simulating Protein-Protein Interaction; VI. Concluding Remarks; Web Sites; References

Chapter 3. Sequences Analysis of Multidomain Proteins: Past Perspectives and Future DirectionsI. Identification of Novel Protein Domain Families; II. Methods for Classifying Protein Domain Families; III. From Domain Classification to Domain context; IV. Genome-Wide Analysis: New Quality in Domain Resarch; V. Conclusion; References; Chapter 4. Identification of Transiently Interacting Proteins and of Stable Protein Complexes; I. Introduction; II. Genetic Approaches; III. Biological Methods; IV. Biochemical Methods; V. Validation of Interactions

VI. Characterization of Interacting Subunits and Dissection of Interaction DomainReferences; Chapter 5. Molecular Recognition in Antibody-Antigen Complexes; I. Introduction; II. Structure of Antibody-Antigen Interfaces; III. Antibody Cross-Reactivity and Molecular Mimicry; IV. Thermodynamic Mapping of Antigen-Antibody Interfaces; V. Dissection of Binding Energetics in Antigen-Antibody Interfaces Using Dobule-Mutant Cycles; VI. Accommodation of Mutations in Antigen-Antibody Interfaces; VII. Functional Roles for Protein Plasticity in Antigen Recognition; VIII. Conclusions; References

Chapter 6. Molecular Recognition by SH2 DomainsI. Introduction; II. Single SH2 Domain Structure; III. Functional Analysis of Single SH2 Domain Binding; IV. Structure and Function of SH2 Domain in the Context of Other Protein Modules; V. Unusual SH2 Domain Interactions; VI. SH2 Domain as Drugs Targets; VII. Summary; References; Chapter 7. How SH3 Domain Recognize Proline; I. Introduction; II. Proline and Polyproline Type II Helices; III. The SH3 Domain: A Model System to Understand Interactions Mediated by Proline-Rich PPH Helices; References

Chapter 8. Structural Biology of elF4F: mRNA Recognition and Preparation in Eukaryotic Translation InitiationI. Introduction; II. Structural Features of Eukaryotic mRNAs; III. General Mechanisms of Cellular, Cap-Dependent Translation Initiation; IV. HEAT Repeats within eIF4G Direct Assembly of Translation Machinery; V. Preparation of the mRNA 5'-UTR for Small Ribosomal Subunit Binding; VI. Conclusion and Perspectives; References; AUTHOR INDEX; SUBJECT INDEX

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-01067-7

9786611010676

0-08-049375-0

OCLC:

437182200