Advances in genetics. Volume eighty four / edited by Theodore Friedmann, Department of Pediatrics, University of California at San Diego, School of Medicine, CA, USA, Jay C. Dunlap, Department of Genetics, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA, Stephen F. Goodwin, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

Format:

Book

Author/Creator:

Friedmann, Theodore.

Contributor:

Friedmann, Theodore, 1935- editor.

Dunlap, Jay C., editor.

Goodwin, Stephen F., editor.

Series:

Advances in genetics ; v. 84.

Advances in genetics, 0065-2660 ; volume 84

Language:

English

Subjects (All):

Genetics.

Physical Description:

1 online resource (viii, 154 pages) : illustrations (chiefly color).

Edition:

First edition.

Place of Publication:

Waltham, MA : Academic Press, 2013.

Language Note:

English

Summary:

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. * Includes methods for testing with ethical, legal, and social implications* Critically analyzes future

Contents:

Front Cover; Advances in Genetics; Copyright; Contents; Contributors; Chapter One: Diverse Roles for MAPK Signaling in Circadian Clocks; 1. Circadian Clocks; 1.1. The beginning; 1.2. Organization of the circadian clock; 2. MAPK Signaling Pathways; 2.1. General organization; 2.2. ERK MAPK; 2.3. p38 MAPK; 2.4. JNK MAPK; 3. The Function of MAPKs in Circadian Input Pathways; 3.1. ERK MAPK pathway; 3.2. ERK signaling through downstream components; 3.3. ERK MAPK in peripheral tissues; 3.4. p38 MAPK pathway; 3.5. p38 MAPK in peripheral tissues; 3.6. JNK MAPK pathway; 3.7. Summary

4. Endogenous Rhythms in MAPK Activation4.1. ERK in the SCN; 4.2. p38 and JNK MAPK; 4.3. Transcriptional regulation of MAPK components; 4.4. Transcriptional regulation of MAPK components in mammalian peripheral tissue; 4.5. Rhythmic MAPK activity gates input to the circadian clock; 5. MAPKs Modulate the Circadian Oscillator; 5.1. ERK-mediated regulation of the circadian oscillator; 5.2. p38-mediated regulation of the circadian oscillator; 5.3. JNK-mediated regulation of the circadian oscillator; 5.4. Future directions; 6. The Role of MAPK Pathways in Circadian Output; 6.1. ERK MAPK pathway

6.2. p38 MAPK pathway6.3. JNK MAPK pathway; 6.4. Future directions; 7. Concluding Remarks; References; Chapter Two: Stakeholder Views on Returning Research Results; 1. Introduction; 2. What is a Research Result?; 3. Guidelines on Returning Research Results; 3.1. Biobanks; 3.2. Population-based studies; 4. Stakeholder Views; 4.1. Researchers; 4.2. IRBs; 4.3. Research participants; 4.3.1. Vulnerable populations: Children; 4.3.2. Underserved minority populations; 4.3.3. Returning research results to relatives of research participants; 5. Extent and Experience with Returning Research Results

6. Overall Analysis of Stakeholder Positions6.1. Ethical; 6.2. Legal; 7. Additional Points to Consider; 7.1. Informed consent for returning research results; 7.2. Communication of research results; 7.3. Impact of returning results to affected versus healthy participants; 7.4. Provision of follow-up care; 7.5. Cost; 8. Moving Forward; Acknowledgment; References; Chapter 3: Mouse Models of Radiation-Induced Cancers; 1. Introduction; 2. RI Leukemia; 2.1. RF model; 2.2. SJL/J model; 2.3. C3H model; 2.4. CBA model; 2.5. Underlying molecular pathologies of RI leukemia; 3. RI Lymphoma

3.1. C57BL model3.2. BALB/c model; 3.3. NFS model; 3.4. Underlying molecular pathologies of RI lymphoma; 4. RI Lung Cancer; 4.1. C3H model; 4.2. RF model; 4.3. BALB/c model; 4.4. Underlying molecular pathologies of RI lung cancer; 5. RI Breast Cancer; 5.1. BALB/c total body irradiation model; 5.2. BALB/c transplantation model; 5.3. Underlying molecular pathologies of RI breast cancer; 6. Discussion and Conclusions; References; Chapter Four: Genomics of Elite Sporting Performance: What little We Know and Necessary Advances; 1. Introduction

2. Overview of the Gene Discovery Approaches in Sports Genetics

Notes:

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed December 9, 2013).

"ISSN: 0065-2660."

ISBN:

9780124077317

0124077315

OCLC:

880853002