Progress in molecular biology and translational science. Volume one hundred and twenty two, Molecular basis of memory / edited by Zafar U. Khan, Universidad de Malaga, Malaga, Spain, E. Chris Muly, Emory University, Atlanta, GA, USA.

Format:

Book

Contributor:

Khan, Zafar U., editor.

Muly, E. Chris, editor.

Series:

Progress in molecular biology and translational science ; v. 122.

Progress in molecular biology and translational science, 1877-1173 ; Volume 122

Language:

English

Subjects (All):

Molecular neurobiology.

Memory.

Physical Description:

1 online resource (xv, 437 pages, 12 unnumbered pages of plates) : illustrations (chiefly color).

Place of Publication:

Waltham, MA : Academic Press, 2014.

Language Note:

English

Summary:

This special volume of Progress in Molecular Biology and Translational Science provides a current overview of how memory is processed in the brain. A broad range of topics are presented by leaders in the field, ranging from brain circuitry to synaptic plasticity to the molecular machinery that contributes to the brain's ability to maintain information across time. Memory systems in the prefrontal cortex, hippocampus and amygdala are considered as well. In addition, the volume covers recent contributions to our understanding of memory from in vivo imaging, optogenetic, electrophysiologic

Contents:

Front Cover; Molecular Basis of Memory; Copyright; Contents; Contributors; Preface; Chapter One: Memory Deficits in Aging and Neurological Diseases; 1. Introduction; 2. Memory Loss in Aging; 2.1. Altered epigenetic regulation; 2.2. Impaired cytoskeletal dynamics; 2.3. Dysregulated extracellular matrix activity; 2.4. Dysfunction of neural networks; 2.4.1. Imaging of brain structure and function; 2.4.2. Synaptic dynamics; 2.4.3. Gamma frequency; 2.5. Impaired neurotransmitter systems; 2.5.1. Dopamine; 2.5.2. Glutamate; 2.5.3. Acetylcholine; 2.5.4. Serotonin; 2.5.5. γ-Aminobutyric acid

2.5.6. Norepinephrine3. Memory Deficit in Alzheimer ́s Disease; 3.1. High amyloid-β peptide; 3.2. Altered tau protein phosphorylation; 3.3. Degeneration of cholinergic neurons in Alzheimer ́s disease; 4. Memory Impairment in Schizophrenia; 4.1. Altered brain circuits; 4.2. Abnormal neurotransmitter systems; 5. Concluding Remarks; Acknowledgments; References; Chapter Two: The "Memory Kinases": Roles of PKC Isoforms in Signal Processing and Memory Formation; 1. Introduction; 2. Distribution of PKC Isoforms; 3. Structure of PKC Isoforms; 4. PKC Isoforms in Signal Transduction

4.1. Synaptic transmission4.2. Ion channels; 4.3. Neurite outgrowth; 4.4. Synaptic plasticity; 4.5. Learning and memory; 5. PKC Inhibitors; 6. PKC Activators; 6.1. Memory-enhancing; 6.2. Restoring synaptic and network functions; 6.3. Antidementia effects; 7. Conclusions; References; Chapter Three: CaMKII: A Molecular Substrate for Synaptic Plasticity and Memory; 1. Memory and Synaptic Plasticity; 2. Molecular Mechanisms of LTP; 3. Synaptic Architecture; 4. Calcium/Calmodulin-Dependent Protein Kinase; 5. CaMKII Isoforms; 6. CaMKII Holoenzyme; 7. CaMKII Regulation

7.1. Thr286 autophosphorylation7.2. Thr305/6 autophosphorylation; 7.3. Regulation by other posttranslational modifications; 7.4. Modulation of CaMKII by dephosphorylation; 7.5. Modulation of CaMKII activity by protein-protein interactions; 8. CaMKII Targeting; 8.1. Spatial and temporal neuronal localization; 8.2. NMDA-type glutamate receptor; 8.3. Actin; 9. AMPAR-Mediated Potentiation; 10. CaMKII and LTD; 11. Concluding Remarks; References; Chapter Four: The Transcription Factor Zif268/Egr1, Brain Plasticity, and Memory; 1. Introduction; 2. Zif268 and the Egr Family of Transcription Factors

2.1. The discovery of Zif2682.2. Zif268 brain expression in developing and adult brain; 2.3. Mechanisms of Zif268 regulation; 2.4. Signaling via Zif268; 3. The Role of Zif268 in Synaptic Plasticity; 3.1. Long-term potentiation; 3.2. Other forms of synaptic plasticity; 4. The Role of Zif268 in Learning and Memory; 4.1. Learning and memory consolidation; 4.2. Systems consolidation; 4.3. Memory reconsolidation; 4.4. Drug memory; 5. Adult Neurogenesis: A New Role for Zif268; 5.1. Mechanisms and function of adult neurogenesis; 5.2. Expression and regulation of Zif268 in newborn neurons

5.3. Functional role of Zif268 in newborn neurons integration

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed February 14, 2014).

"ISSN: 1877-1173."

ISBN:

9780124202009

0124202004

OCLC:

881096602