Advances in clinical chemistry. Volume sixty four / edited by Gregory S. Makowski, Clinical Laboratory Partners, Newington, CT, Hartford Hospital, Hartford, CT.

Format:

Book

Contributor:

Makowski, Gregory S., editor.

Series:

Advances in Clinical Chemistry

Advances in clinical chemistry ; volume sixty four

Language:

English

Subjects (All):

Clinical chemistry.

Physical Description:

1 online resource (322 p.)

Edition:

First edition.

Place of Publication:

San Diego : Elsevier, 2014.

Language Note:

English

Summary:

Volume 64 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory. Expertise of international contributorsLatest cutting-edge technologiesComprehensive in scope

Contents:

Front Cover; Advances in Clinical Chemistry; Copyright; Contents; Contributors; Preface; Chapter One: Matrix Metalloproteinases in Coronary Artery Disease; 1. Introduction; 2. Classification, Structure, and Function of MMP; 3. Regulation of MMP; 3.1. Inactive zymogens; 3.2. Transcriptional regulation; 3.3. Translational regulation; 3.4. Tissue inhibitors of metalloproteinases; 4. MMP in Cardiovascular System Development; 4.1. MMP in vasculogenesis and angiogenesis; 4.2. MMP in cardiac tube formation and looping; 4.3. MMP in heart septation; 4.4. MMP in embryonic and fetal cardiac remodeling

5. MMP in Coronary Artery Disease5.1. MMP in atherosclerosis; 5.1.1. MMP and atherosclerotic risk factors; 5.2. MMP in plaque instability; 5.3. MMP in acute coronary syndrome; 5.4. MMP in vascular remodeling; 5.5. MMP in restenosis; 6. Genetics of Matrix Metalloproteinases; 6.1. Studies on genetically modified animals in vascular remodeling and atherosclerosis; 6.2. Genetic predisposition to CAD in humans; 6.2.1. MMP gene polymorphisms in CAD; 6.2.1.1. MMP-1 gene polymorphism; 6.2.1.2. MMP-2 gene polymorphism; 6.2.1.3. MMP-3 gene polymorphism; 6.2.1.4. MMP-9 gene polymorphism

6.2.1.5. Other polymorphisms of MMP genes6.2.2. MMP gene polymorphisms in restenosis; 7. Matrix Metalloproteinases and Therapeutic Aspects; 8. Prognostic Value of ECM Biomarkers; 9. Conclusion; Acknowledgments; References; Chapter Two: Heat Shock Proteins and Cardiovascular Disease; 1. Introduction; 1.1. Cardiovascular disease; 1.1.1. Atherosclerosis; 1.1.1.1. Atherosclerosis and inflammation; 1.1.1.2. The potential role of infection in atherogenesis; 1.1.1.3. Autoimmunity in atherogenesis; 1.2. Heat shock proteins; 1.2.1. Production of HSPs; 1.2.2. HSP in the extracellular space

2. Atherogenesis and HSP2.1. HSPs and CVD in animal models; 2.2. HSPs and CVD in human studies; 2.2.1. Atherogenesis and HSP20; 2.2.2. Atherogenesis and HSP27; 2.2.3. Atherogenesis and HSP60/65; 2.2.4. Atherogenesis and HSP70; 2.3. Molecular mimicry; 2.4. HSP and risk factors of atherosclerosis; 2.5. The role of HSPs in other common CVDs; 2.5.1. Cardiac hypertrophy; 2.5.2. Heart failure; 2.5.3. Ischemic cardiac injury; 3. Therapeutic Implications; 4. HSPs as Predictors of CVD; 5. Immunization and Vaccination with HSP; 6. Effects of Therapeutic Interventions on HSP; 6.1. Herbal medicines

6.2. Statin therapy7. Conclusion; References; Chapter Three: Apolipoprotein B-48: A Unique Marker of Chylomicron Metabolism; 1. Introduction; 2. Discovery of apoB48; 3. ApoB48 and mRNA Editing; Stop Codon and Translational Termination of Intestinal apoB mRNA; 4. ApoB-48, MTP, and apoA-IV in CM Formation; 5. Metabolism of apoB-48 Containing CM, apoB-100 Containing VLDL, and Their Remnants in Plasma; 6. Biochemistry of CM and VLDL Remnants; 7. ApoB-48 Receptor; 8. Kinetics of apoB-48 Containing Lipoproteins

9. Daily Rhythm of Plasma TG, apoB-48, and Remnant Lipoproteins and Their Changes After Fat Load

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed April 24, 2014).

ISBN:

9780128003046

0128003049