Nitric oxide / series editor, Gerald Litwack.

Format:

Book

Contributor:

Gerald, Litwack, editor.

Series:

Vitamins and hormones ; Volume 96.

Vitamins And Hormones ; Volume 96

Language:

English

Subjects (All):

Nitric oxide--Physiological effect.

Nitric oxide.

Nitrous oxide.

Physical Description:

1 online resource (483 p.)

Place of Publication:

Waltham, Massachusetts : Elsevier, 2014.

Language Note:

English

Summary:

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on nitric oxide. Key features: Expertise of the contributorsCoverage of a vast array of subjectsIn depth

Contents:

Front Cover; Nitric Oxide; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Regulation of Nociceptive Transduction and Transmission by Nitric Oxide; 1. Introduction; 2. Role of NO in Nociceptive Transduction at the Periphery; 3. Diverse Effects of NO on Ion Channels Expressed on Primary Sensory Neurons; 3.1. Acid-sensing ion channels; 3.2. Transient receptor potential channels; 3.2.1. TRPV1; 3.2.2. TRPA1; 3.2.3. TRPV3 and TRPV4; 3.3. KATP channels; 4. Role of NO in Regulating Nociceptive Transmission at the Spinal Cord Level

5. NO Reduces Excitatory, But Potentiates Inhibitory, Synaptic Transmission in Spinal Cords5.1. Glutamatergic input from primary afferent nerves; 5.2. Voltage-activated calcium channels in sensory neurons; 5.3. Synaptic NMDA receptors; 5.4. Synaptic release of glycine; 6. Conclusions and Future Directions; Acknowledgments; References; Chapter Two: microRNA and Human Inducible Nitric Oxide Synthase; 1. Introduction; 2. Regulation of Human iNOS Gene; 2.1. Transcriptional; 2.2. Posttranscriptional; 3. miRNAs Regulation; 3.1. miR-939; 3.2. other miRNAs; 4. Conclusion; References

Chapter Three: Heart Mitochondrial Nitric Oxide Synthase: A Strategic Enzyme in the Regulation of Cellular Bioenergetics1. Introduction; 2. Heart Mitochondrial NO Production; 2.1. Heart mtNOS activity; 2.2. Heart mtNOS identity; 3. Regulation of Heart mtNOS; 3.1. Effect of substrates and cofactors; 3.2. Effect of mitochondrial metabolic state and membrane potential; 4. Effects of NO on Heart Mitochondrial Function; 4.1. Nitric oxide consumption reactions in mitochondria; 4.2. Regulation of mitochondrial function by NO; 4.3. Mitochondrial NOS functional activity

5. Physiopathological Regulation of Heart mtNOS5.1. Heart chronic hypoxia; 5.2. Heart acute hypoxia and ischemia-reperfusion; 6. Conclusions and Future Directions; Acknowledgments; References; Chapter Four: Nitric Oxide Regulation of Adult Neurogenesis; 1. Introduction; 2. Adult Neurogenesis; 3. Expression of NOS in Neurogenic Regions; 4. Pharmacological Studies of NO on Adult Neurogenesis In Vivo; 5. NOS Knockout Animals and Adult Neurogenesis; 6. Neuropeptide Y and NO; 7. The Dual Role of NO in Adult Neurogenesis; 8. Concentration-Dependent Effects of NO; 9. Conclusions; References

Chapter Five: Nitric Oxide in the Nervous System: Biochemical, Developmental, and Neurobiological Aspects1. Introduction; 1.1. Brief history and biochemistry of NOS; 1.2. NO classical actions; 1.3. Interesting partners in the CNS: Focusing on NMDA receptors; 2. NO Signaling Pathways; 2.1. PKG modulation by NO; 2.2. AKT modulation by NO; 2.3. ERK1/2 modulation by NO; 2.4. Src modulation by NO; 2.5. CREB modulation by NO; 3. NO and Neuronal Viability; 4. NO and Neurotransmitters Release; 4.1. Glutamate release; 4.2. GABA release; 4.3. DA release; 4.4. 5-Hydroxytryptamine release

5. NO and Neuroplasticity

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed August 22, 2014).

ISBN:

0-12-800439-8