Vitamins and hormones. Volume 80, Insulin and IGFs / editor-in-chief, Gerald Litwack.

Format:

Book

Contributor:

Litwack, Gerald.

Series:

Vitamins and hormones ; v. 80.

Vitamins and hormones ; v. 80

Language:

English

Subjects (All):

Vitamins.

Hormones.

Physical Description:

1 online resource (766 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam ; Boston : Academic Press, 2009.

Language Note:

English

Summary:

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologica

Contents:

Front Cover; Vitamins and Hormones Insulin and IGFs; Copyright Page; Contents; Preface; Chapter 1: The Human Insulin Superfamily of Polypeptide Hormones; I. Introduction; II. Relaxin Peptide Hormone Subfamily; III. Concluding Remarks; Acknowledgments; Chapter 2: The Structure and Function of Insulin: Decoding the TR Transition; I. Introduction; II. Structure-Activity Relationships; III. Implications for the Genetics of Diabetes Mellitus; IV. Concluding Remarks; Acknowledgments; References; Chapter 3: Molecular Mechanisms of Differential Intracellular Signaling From the Insulin Receptor

I. OverviewII. Insulin and the IR; IV. Differential Activation of the IR; V. Conclusions/Final Words; References; Chapter 4: c-Abl and Insulin Receptor Signalling; III. Metabolic Versus Mitogenic Effect of IR; IV. c-Abl Tyrosine Kinase; V. c-Abl and IR Signalling; Acknowledgments; Chapter 5: CXCL14 and Insulin Action; I. Introduction; II. Basic Properties of CXCL14; IV. Novel Functions of CXCL14 Revealed by Knockout Mice; V. Signal Cross-Talk Between CXCL14 and Insulin; VII. Conclusions; References; Chapter 6: Crosstalk Between Growth Hormone and Insulin Signaling; I. Introduction

II. GH SignalingIII. Insulin Signaling; Chapter 7: Intracellular Retention and Insulin-Stimulated Mobilization of GLUT4 Glucose Transporters; I. Introduction; II. GLUT4 Storage Vesicles (GSVs); III. Insulin-Regulated Aminopeptidase (IRAP); IV. Stability and Trafficking of GLUT4 and IRAP; V. TUG, an Essential Component of a Retention Receptor for GLUT4; VI. From What Membranes do GSVs Originate?; VIII. Conclusions; Chapter 8: Compartmentalization and Regulation of Insulin Signaling to GLUT4 by the Cytoskeleton; I. Introduction; II. Insulin Signaling to GLUT4 Vesicles; IV. GLUT4 Vesicle Fusion

V. ConclusionsAcknowledgments; Chapter 9: Nutrient Modulation of Insulin Secretion; I. Introduction; II. Overview of Insulin Secretion; III. Nutrient Regulation of Insulin Secretion; References; Chapter 10: How Insulin Regulates Glucose Transport in Adipocytes; I. Introduction; II. Historical Perspective; III. Current Views and Controversies; IV. Conclusions and Future Directions; Chapter 11: Spatio-Temporal Dynamics of Phosphatidylinositol-3,4,5-Trisphosphate Signalling; I. Introduction; III. Real-Time Measurements of PIP3 in Living Cells; IV. Spatio-Temporal Patterns of PIP3 Signals

VII. Concluding RemarksAcknowledgments; References; Chapter 12: Serine Kinases of Insulin Receptor Substrate Proteins; I. Introduction; III. Regulation of Insulin and IGF-1 Signaling: Role of Ser/Thr Phosphorylation of IRS Proteins; IV. The Consequences of Ser Phosphorylation of IRS Proteins; VI. Summary; Chapter 13: Phosphorylation of IRS Proteins: Yin-Yang Regulation of Insulin Signaling; I. Introduction; II. Discovery of the IRS Proteins; III. Molecular Structure of the IRS Proteins; IV. Biological Function of IRS Proteins in Insulin Action

V. The Role of IRS Serine Phosphorylation in Mediating the Crosstalk with Other Signaling Pathways

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-282-12089-1

9786612120893

0-08-092215-5

OCLC:

317980524