The enyzmes. Volume 26, Glycosylphosphatidylinositol (GPI) anchoring of proteins / edited by Anant K. Menon, Taroh Kinoshita, Peter Orlean, Fuyuhiko Tamanoi.

Format:

• Book

Contributor:

• Menon, Anant Kumar.
• Knoshita, Taroh.
• Orlean, Peter.
• Tamanoi, Fuyuhiko.

Series:

• The enyzmes ; 26

Language:

English

Subjects (All):

• Glycoproteins.
• Proteins.

Physical Description:

1 online resource (434 p.)

Place of Publication:

London : Academic Press, 2009.

Language Note:

English

Summary:

This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins.* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Contents:

• Front Cover; The Enzymes; Copyright; Contents; Preface; Chapter 1: Overview of GPI Biosynthesis; I. Abstract; II. Introduction of GPI-Anchored Proteins; III. Structure of GPI-APs; IV. Biosynthesis of GPI and Attachment to Proteins; V. Lipid Remodeling of GPI and GPI-APs; VI. Enzymes Involved in Modification of GPI Glycan in GPI-APs; Chapter 2: The N-Acetylglucosamine-PI Transfer Reaction, the GlcNAc-PI Transferase Complex, and Its Regulation; I. Abstract; VI. Concluding Remarks; Chapter 3: The GlcNAc-PI de-N-acetylase: Structure, Function, and Activity; I. Abstract
• III. Protein Structure and FunctionIV. Recombinant Protein Expression; V. Activity Assays; VI. Enzyme Substrate Specificity; References; Chapter 4: Inositol Acylation/Deacylation; I. Abstract; III. Variations in Inositol Acylation/Deacylation Among Organisms; IV. Enzymes Involved in Inositol Acylation/Deacylation and Their Functions; V. Perspective and Concluding Remarks; Acknowledgments; References; Chapter 5: Mannosylation; I. Abstract; II. Overview of Biosynthetic Pathway for GPI Mannosylation; III. Dol-P-Man as a Substrate for GPI-Man-Ts
• VI. Substrate Specificities and Inhibitors for MannosylationsIX. Mycobacteria Genes Homologous to Mammalian PIG-M; References; Chapter 6: Phosphoethanolamine Addition to Glycosylphosphatidylinositols; I. Abstract; II. Sites of Etn-P Modification on Protein-Bound and Free GPIs; IV. Proteins Involved in Etn-P Addition; References; Chapter 7: Attachment of a GPI Anchor to Protein; I. Abstract; II. The GPI Signal Sequence; IV. GPI Transamidase (GPIT); Acknowledgements; References; Chapter 8: Split Topology of GPI Biosynthesis; I. Abstract
• II. Synthesis and De-N-Acetylation of GlcNAc-PI Occur on the Cytoplasmic Face of the ERVI. Conclusion; References; Chapter 9: GPIs of Apicomplexan Protozoa; I. Abstract; II. Introduction: Apicomplexan Parasites; IV. Immunological Functions of Protozoan GPIs; References; Chapter 10: Chemical Synthesis of Glycosylphosphatidylinositol (GPI) Anchors; I. Abstract; IV. Synthesis of GPI Anchor of Saccharomyces cerevisiae (Yeast); V. Synthesis of GPI Anchor of Rat Brain Thy-1; References; Chapter 11: GPI-Based Malarial Vaccine: Past, Present, and Future; I. Abstract
• IV. Synthetic GPI Microarray to Define Antimalarial Antibody ResponseAcknowledgments; References; Chapter 12: Inhibitors of GPI Biosynthesis; I. Abstract; V. GlcNAc-PI De-N-Acetylase; XIV. GPI Lipid Remodelling; XVII. Perspectives; References; Chapter 13: Transport of GPI-Anchored Proteins: Connections to Sphingolipid and Sterol Transport; I. Abstract; II. ER Exit of GPI-Anchored Proteins; IV. Defects in GPI-Anchored Protein Trafficking and Folding; VI. Parallels and Differences between Yeast and Mammalian Cells
• Chapter 14: Mechanisms of Polarized Sorting of GPI-anchored Proteins in Epithelial Cells

Notes:

• Description based upon print version of record.
• Includes bibliographical references and index.

ISBN:

• 1-282-28947-0
• 9786612289477
• 0-08-096095-2

OCLC:

495852166