Translational control in health and disease / edited by John W.B. Hershey.

Format:

• Book

Contributor:

• Hershey, John W. B.

Series:

• Progress in molecular biology and translational science ; v. 90.
• Progress in molecular biology and translational science, 1877-1173 ; v. 90

Language:

English

Subjects (All):

• Genetic translation.
• Genetic regulation.
• Nucleic acids.

Physical Description:

1 online resource (437 p.)

Place of Publication:

London : Academic Press, 2009.

Language Note:

English

Summary:

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology and translational science. It contains contributions from leaders in their fields and abundant references. This volume focuses on translational control in health and disease. * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Contents:

• Front Cover; Molecular Biology and Translational Science: Translational Control in Health and Disease; Copyright Page; Contents; Contributes; Preface; Chapter 1: Molecular Basis of Translational Control; I. Introduction; II. Initiation Pathway Overview; III. Generating a Pool of 40S Ribosomal Subunits; IV. Preparing the 40S Subunit for Binding mRNA; V. eIF1 and eIF1A; VI. Initiator tRNA Recruitment to the 40S Subunit; VII. Regulating Ternary Complex Availability; VIII. The Role of eIF3 in 43S Complex Formation; IX. eIF5; X. Controlling mRNA Recruitment to the 40S Subunit
• XI. Eukaryotic mRNA CharacteristicsXII. Recruitment of mRNA to the 43S Complex; XIII. Ribosomal Scanning and Initiation Codon Recognition; XIV. Ribosomal Subunit Joining; XV. Regulating the Initiation Pathway; XVI. The Mechanism of Translation Elongation; XVII. Translation Termination; XVIII. Perspectives; References; Chapter 2: 2 Cell Signaling in Protein Synthesis: Ribosome Biogenesis and Translation Initiation and Elongation; I. Introduction; II. Translation: The Regulated Steps of Ribosome Biogenesis and Translation Initiation and Elongation
• III. Signaling Pathways that Control TranslationIV. Signaling and Translation Initiation; V. Signaling and Elongation; VI. Signaling and Ribosome Biogenesis; Acknowledgment; References; Chapter 3: Protein S6 Kinase: From TOP mRNAs to Cell Size; I. S6 Kinases; II. S6K Substrates and Interactors; III. Does S6K Regulate the Translation Efficiency of TOP mRNAs?; IV. Physiological Roles of S6K; V. Concluding Remarks; Acknowledgment; References; Chapter 4: Regulation of Translation by Stress Granules and Processing Bodies; I. Introduction; II. Early History of Stress Granules
• III. Stress Granules-Basic AttributesIV. Processing Bodies/EGP Bodies/SGs in Yeast; V. Metazoan PBs Versus GWBs; VI. SG Assembly-Mechanisms and Model; VII. Functions and Consequences of SG/PB Assembly; VIII. SG/PB Dynamics; IX. SGs and PBs in Disease; X. Conclusions; References; Chapter 5: MicroRNA-Mediated Gene Silencing; I. Introduction; II. Biogenesis of MicroRNAs; III. Mechanisms of MicroRNA-Mediated Regulation; IV. Subversion of Liver-Specific MicroRNA miR-122 by HCV; V. Antagomir Approaches to Study MicroRNA Targets; VI Concluding Remarks; References
• Chapter 6: Translational Control During Early DevelopmentI. Introduction; II. Essential Background; III. Translational Control Mechanisms that Pattern the Early Drosophila Embryo; IV. Cytoplasmic Regulation of Polyadenylation: A Widespread Mechanism of Translational Control Underlying Cellular Asymmetries; V. Polar Granules, P Granules, and Related Germline-Specific Organelles as Sites of Specialized Translation; VI. Translational Regulation of Maternal mRNAs Outside P Granules in C. elegans; VII. Translational Control of Localized mRNAs in the Xenopus Oocyte
• VIII. Links Between Embryonic Translational Regulators and Human Disease

Notes:

• Description based upon print version of record.
• Includes bibliographical references and index.

ISBN:

• 1-282-61807-5
• 9786612618079
• 0-08-091196-X

OCLC:

657739229