Advances in virus research. Volume 74 / edited by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy.

Format:

Book

Contributor:

Maramorosch, Karl.

Shatkin, Aaron J.

Murphy, Frederick A.

Series:

Advances in virus research ; 74.

Advances in virus research ; 74

Language:

English

Subjects (All):

Virology--Research.

Virology.

Microbiology--Research.

Microbiology.

Physical Description:

1 online resource (161 p.)

Place of Publication:

Amsterdam : Academic Press, 2009.

Language Note:

English

Summary:

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2008 is 4.886, placing it 4th in the highly competitive category of virology. * Contributions from leading authorities * Informs and updates on all the latest developments in the field

Contents:

Front Cover; Advances in Virus Research; Copyright Page; Contents; Chapter 1: Regulation of HIV-1 Alternative RNA Splicing and Its Role in Virus Replication; I. Introduction; II. HIV-1 Splicing Regulatory Elements; A. Cis-regulatory elements that activate and repress metazoan mRNA splicing; 1. Core splicing signals and exon definition; 2. Exonic and intronic splicing enhancers and silencers; 3. Role of secondary structure; B. General strategy of HIV-1 RNA splicing; C. Intrinsic efficiency of HIV-1 splice sites; D. HIV-1 splice sites and their regulatory elements

H. Possible roles of HIV-1 Rev, Tat, and Vpr proteins in regulation of viral RNA splicingIII. Evidence for the Functional Importance of HIV-1 Splicing Regulatory Elements in Virus Replication; A. Sequence comparison of HIV-1 splice sites and regulatory elements; B. Mutations of HIV-1 regulatory elements inhibit virus replication; C. Overexpression and siRNA inhibition of cellular splicing factors affect HIV-1 splicing and inhibit virus replication; D. Changes in expression of cellular splicing factors during HIV-1 infection; IV. Strategies to Target HIV-1 Splicing with Antiviral Drugs

2. The flavivirus RdRp can initiate RNA synthesis de novo3. Requirements for de novo initiation; 4. Template requirements for RNA synthesis; C. RdRp structure; 1. Overall NS5 RdRp structure; 2. The palm subdomain; 3. The fingers subdomain; 4. The thumb subdomain; 5. Initiation of RNA synthesis; 6. Structure of the full-length NS5; D. Structure-function analysis; IV. NS5 Interactions; A. NS5 intramolecular interactions; B. The interaction of NS5 with viral RNA; C. The interaction of NS3 and NS5; D. The interaction of NS5 with host proteins; V. NS5 Phosphorylation; VI. NS5 Localization

A. Cellular localization of NS5

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-282-38186-5

9786612381867

0-12-378588-X

OCLC:

808998525