Tissue-specific vascular endothelial signals and vector targeting. Part B / edited by Renata Pasqualini.

Format:

Book

Contributor:

Pasqualini, Renata.

Series:

Advances in genetics ; v. 69.

Advances in genetics, 0065-2660 ; v. 69

Language:

English

Subjects (All):

Adenoviruses.

Cancer--Genetic aspects.

Cancer.

Gene targeting.

Gene therapy.

Genetic vectors.

Tissue-specific antigens.

Vascular endothelium.

Physical Description:

1 online resource (174 p.)

Place of Publication:

Amsterdam : Academic, 2009.

Language Note:

English

Summary:

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. * Includes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, providing researchers an overview and synthesis of the latest findings in the area * Presents up-to-date research from leaders in the field

Contents:

Front Cover; Volume 69: Tissue-Specific Vascular Endothelial Signals and Vector Targeting, Part B; Copyright page; Contents; Contributors; Chapter 1: MR Molecular Imaging of Tumor Vasculature and Vascular Targets; Abstract; I. Introduction; II. Structural, Functional, and Molecular Characteristics of Tumor Vasculature; III. Basis of Contrast in MR Images; IV. Imaging Receptor Expression; V. Imaging Vascular Targeting; VI. Multimodal Molecular-Functional Imaging of Tumor Vasculature; VII. Conclusion; Acknowledgments; References

Chapter 2: An Integrated Approach for the Rational Design of Nanovectors for Biomedical Imaging and TherapyAbstract; I. Introduction; II. Three Generations of Nanovectors; III. Mathematical Models for Predicting the Nanovectors' Behavior; IV. Biophysical Characterization of Nanovectors; V. Vascular Targeting Moieties; VI. In vitro Assays for Nanovectors' Characterization; VII. Intravital Video Microscopy; VIII. Conclusions; Acknowledgments; Chapter 3: Targeted Systemic Gene Therapy and Molecular Imaging of Cancer; Abstract; I. Introduction; II. Targeted Gene Delivery

III. Conclusions and PerspectivesReferences; Chapter 4: Cationic and Tissue-Specific Protein Transduction Domains; Abstract; I. Introduction; II. Cationic Protein Transduction Domains; III. Biopanning using Peptide Phage Display Libraries; IV. Peptide Phage Display Biopanning in Cell Culture for Transduction Peptides; V. Methods for Analysis of Transduction Efficiency; VI. Peptide Phage Display Biopanning in vivo for Transduction Peptides; VII. PTDs as Therapeutics; VIII. Conclusions; References; Chapter 5: GRP78 Signaling Hub; Abstract; Abbreviations; I. Introduction

II. GRP78 Association with Activated α2-Macroglobulin Promotes Cell ProliferationIII. GRP78 Autoantibody Predicts Poor Prognosis in Tumors but Shows Therapeutic Effects in Rheumatoid Arthritis...; IV. GRP78 Promotes Endothelial Cell Survival in Association with T-Cadherin; V. Cripto Mitogenic Signaling is GRP78-Dependent; VI. Interaction of GRP78 with Plasminogen Kringle 5 and Microplasminogen Leads to Apoptosis or the UPR; VII. GRP78 Association with Extracellular Par-4 Activates the Extrinsic Apoptotic Pathway; VIII. GRP78 Inhibits Tissue Factor-Mediated Procoagulant Activity

IX. GRP78 Targeting Peptides Inhibit Tumor GrowthX. Conclusions; References; Chapter 6: On the Synergistic Effects of Ligand-Mediated and Phage-Intrinsic Properties During In Vivo Selection; Abstract; I. Introduction; II. Ligand-Receptor Mediated Effects; III. Synergistic Effects Intrinsic to Phage; IV. Conclusion; References; Chapter 7: Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy; Abstract; I. Introduction; II. Isolated Limb Perfusion; III. Isolated Liver Perfusion; IV. Chemoembolization

V. Gene Therapy Strategies Available to Target the Tumor and the Tumor-Associated Vasculature

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-282-87885-9

9786612878855

0-08-096260-2

OCLC:

689523979