Organogenesis in development / edited by Peter Koopman.

Format:

Book

Contributor:

Koopman, Peter.

Series:

Current topics in developmental biology ; v. 90.

Current topics in developmental biology, 0070-2153 ; v. 90

Language:

English

Subjects (All):

Morphogenesis.

Biology.

Physical Description:

1 online resource (455 p.)

Place of Publication:

San Diego : Academic Press, 2010.

Language Note:

English

Summary:

Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians. Summarizes the key morphological and cellular events Emphasizes up-to-date research relating to molecular control mech

Contents:

Cover; Current Topics in Developmental Biology; Copyright; Contents; Contributors; Preface; Chapter 1. How to Make a Heart: The Origin and Regulation of Cardiac Progenitor Cells; 1. Introduction; 2. The Origin of the Heart Fields and Cardiac ProgenitorCell Behavior; 3. Markers of Cardiac Progenitors and the Distinction Between Firstand Second Heart Fields (FHF and SHF); 4. Cardiac Progenitor Contributions to the Cell Types of the Heart; 5. Subdomains of the SHF; 6. Molecular Mechanisms that Govern SHF Cell Behavior-Transcriptional Regulators and Signaling Pathways; 7. Conclusion

AcknowledgmentsReferences; Chapter 2. Vascular Development-Genetic Mechanisms and Links to Vascular Disease; 1. Introduction; 2. VEGF in Vascular Development; 3. BMP in Vascular Development; 4. Notch/Delta/Jagged in Vascular Development; 5. Perspectives; Acknowledgments; References; Chapter 3. Lung Organogenesis; 1. Introduction; 2. Developmental Anatomy of the Lung; 3. Molecular Embryology of the Lung; 4. Mechanobiology of the Developing Lung; 5. Stem/Progenitor Cell Biology of the Lung; 6. Postnatal and Adult Lung; 7. Conclusions; Acknowledgments; References

Chapter 4. Transcriptional Networks and Signaling Pathways that Govern Vertebrate Intestinal Development1. Introduction; 2. Formation of the Definitive Endoderm; 3. The Formation and Regionalization of the Primitive Gut Tube 1654. Establishment of the Crypt-Villus Axis; 4. Establishment of the Crypt-Villus Axis; 5. Establishing the Stem Cell Niche and Homeostasis in the Intestinal Epithelium; 6. Role of Intestinal Development Pathways in Cancer; Acknowledgments; References; Chapter 5. Kidney Development: Two Tales of Tubulogenesis; 1. Introduction: How You Get a Kidney

2. The First Tale of Tubulogenesis: a Branching Tree3. Tubulogenesis Via MET-Tube One Induces Tube Two; 4. Patterning the Resulting Tubules; 5. Moving From Structure to a Functional Filter; 6. Disruptions to Kidney Tubulogenesis in Human Disease; 7. Conclusion; Acknowledgments; References; Chapter 6. The Game Plan: Cellular and Molecular Mechanisms of Mammalian Testis Development; 1. Introduction; 2. Introducing the Players: Cell Biology and Morphologyof the Gonads; 3. Origin of Sertoli Cells; 4. Kickoff in Testis Determination: Sry and Sertoli Cell Specification

5. The Goalkeeper: Sox9 and Sertoli Cell Differentiation6. Forward Players: Beyond Sox9; 7. The Sweepers: Peritubular Myoid Cells; 8. Interplay Between PM and Other Testicular Cells; 9. The Midfielders: Leydig Cells; 10. The White Lines: Endothelial Cells; 11. What All the Fuss Is About: Germ Cells; 12. Concluding Remarks; Acknowledgments; References; Chapter 7. Building Pathways for Ovary Organogenesis in the Mouse Embryo; 1. Evolution of the Hypotheses for Ovary Organogenesis in Mammals; 2. Building the Foundation: Morphogenesis of the Ovary

3. Making Eggs: Establishment of the Female Germline

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786612879166

9781282879164

1282879162

9780123809131

0123809134

OCLC:

669748403