The Dentate Gyrus : a comprehensive guide to structure function and clinical implications / edited by Helen E. Scharfman.

Format:

Book

Contributor:

Scharfman, Helen E.

Series:

Progress in brain research

Language:

English

Subjects (All):

Dentate gyrus.

Physiology.

Physical Description:

1 online resource (841 p.)

Place of Publication:

London : Elsevier, 2007.

Language Note:

English

Summary:

The dentate gyrus is a part of the brain that has been a topic of intense interest since the beginning of neuroscience, and pioneering studies from the distant and recent past attest to this. One of the reasons for such interest is that this structure provides some of the most remarkable examples of plasticity within the nervous system. In addition, it is critical to normal cognitive function, although exactly how and when is still a question that eludes answers. Furthermore, abnormalities within the dentate gyrus appear to play a role in diverse clinical conditions, from depression to epile

Contents:

Front cover; The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications; Copyright page; List of contributors; Preface; Contents; Section I: Functional Organization and Development; Chapter 1. The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies); Introduction; Overall organization; Comparative neuroanatomy of the dentate gyrus; Major cell types of the dentate gyrus - and their connections; Conclusions; References

Chapter 2. Comparative anatomy of the hippocampal dentate gyrus in adult and developing rodents, non-human primates and humansGranule cells; Mossy cells; Local circuit neurons; Chemical neuroanatomy; Afferent and efferent connections: connections between the dentate gyrus and Ammon's horn; Comparative developmental features of the rodent and primate dentate gyrus; Abbreviations; Acknowledgments; References; Chapter 3. The perforant path: projections from the entorhinal cortex to the dentate gyrus; Introduction; Nomenclature; Fiber pathways; Layers of origin in the entorhinal cortex

Radial or layered terminal organization in the dentate gyrusTransverse organization in the dentate gyrus; Longitudinal organization of entorhinal-dentate projections; Contralateral projections; Synaptic organization of the entorhinal-dentate projection; Summary and functional comments; Acknowledgments; References; Chapter 4. Extrinsic afferent systems to the dentate gyrus; Introduction and anatomical overview; Septo-hippocampal connections; Supramamillo-dentate connections; Catecholaminergic brainstem-dentate connections; Commissural connections of the dentate gyrus

Glutamatergic innervation of the dentate gyrusConclusion; Acknowledgments; References; Chapter 5. The dentate mossy fibers: structural organization, development and plasticity; Introduction to the dentate mossy fiber system; Visualization of dentate mossy fibers and terminals; Trajectory and termination of mossy fibers in CA3 (regio inferior); Mossy fibers projections to CA1 (regio superior); Mossy fiber connections in the dentate hilus (CA4); Structure of synaptic mossy fiber connections in the dentate hilus and CA3; New emerging structural plasticity of individual mossy fiber terminals

Development of the dentate mossy fiber systemExperimental studies on structural and connective plasticity of dentate mossy fibers, including dentate transplants; Acknowledgment; References; Chapter 6. Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3; MF anatomy: does form follow function?; Excitatory-inhibitory conductance sequence; Properties of transmitter release from MF synapses; Quantal nature of transmission at the MF-CA3 pyramidal neuron synapse; Evidence for multiple neurotransmitters/modulators in the granule cells; Presynaptic modulation

Co-localization of plasma membrane transporters of glutamate and GABA

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611034528

9781281034526

1281034525

9780080551753

0080551750

OCLC:

476103675