Advances in immunology. Volume 105 / edited by Frederick W. Alt ; associate editors, K. Frank Austen ... [et al.].

Format:

Book

Contributor:

Alt, Frederick W.

Austen, K. Frank (Karl Frank)

Series:

Advances in immunology.

Advances in immunology, 0065-2776

Language:

English

Subjects (All):

Immunology.

Physical Description:

1 online resource (236 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam ; Boston : Elsevier, 2010.

Language Note:

English

Summary:

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future.* Contributions from leading authorities and industry experts * Informs and updates on all the latest developme

Contents:

Front Cover; Advances in Immunology; Copyright Page; Contents; Contributors; Chapter 1: Learning from Leprosy: Insight into the Human Innate Immune Response; 1. Leprosy as a Model; 2. Recognition of M. leprae by the Innate Immune System; 2.1. Toll-like receptor 2/1 (TLR2/1); 2.2. TLR2 and TLR1 SNPs; 2.3. Other TLRs and PRRs; 3. Phagocytosis of Mycobacteria; 3.1. Evasion of phagosome-lysosomal fusion by mycobacteria; 3.2. Pathogenic foam cell formation in mycobacterial infection; 4. Antimicrobial Activity; 4.1. Vitamin D and innate immunity

4.2. Divergence of macrophage phagocytic and antimicrobial programs in leprosy5. Dendritic Cell Function in Leprosy; Acknowledgments; References; Chapter 2: The Immunological Functions of Saposins; 1. Introduction; 2. Saposins in Lysosomal Glycosphingolipid Degradation and Membrane Digestion; 2.1. Prosaposin; 2.2. Saposin A; 2.3. Saposin B; 2.4. Saposin C; 2.5. Saposin D; 2.6. The GM2 activator; 2.7. Topology; 3. Saposins Facilitate Lipid Presentation to CD1-Restricted T Lymphocytes; 3.1. Characteristics of antigen-presenting CD1 molecules; 3.2. Intracellular trafficking of CD1 molecules

3.3. CD1-restricted T cells3.4. CD1d-restricted natural killer T cells; 4. SAPs Stimulate the Processing of Lipid Antigens by Lysosomal Glycosidases; 4.1. Hexosaminidase B; 4.2. α-Galactosidase A; 4.3. α-Mannosidase; 5. Saposins Disrupt Vesicles Released by Apoptotic Cells; 5.1. Implications for apoptosis; 5.2. Saposins facilitate antigen cross-presentation; 6. SAP-Like Proteins in Antimicrobial Defense; 7. Conclusions; References; Chapter 3: OX40-OX40 Ligand Interaction in T-Cell-Mediated Immunity and Immunopathology; 1. Introduction

2. Impact of the OX40 Costimulatory Signal in Immune Responses2.1. The OX40-OX40L interaction in effector T-cell function; 2.2. OX40L expressed by cells other than professional APCs; 3. OX40 in the Function and Development of Regulatory T Cells; 3.1. OX40 and the homeostasis of naturally occurring regulatory T cells; 3.2. Role of OX40 in the function of nTreg cells; 3.3. Role of OX40 in tumor immunity controlled by Treg cells; 3.4. Effects of OX40 on the development of adaptively induced Treg cells; 3.5. Perspectives

4. OX40-OX40L Interaction in the Generation and Homeostasis of Memory T Cells4.1. Role of OX40 in the generation and reactivation of memory CD4 T cells; 4.2. Differential requirement for OX40 in the generation of heterogeneous CD4 memory T cells; 4.3. OX40 potentiates the generation and maintenance of memory CD8 T cells; 5. The OX40 and OX40L Interaction in Disease; 5.1. Advantages of immunotherapy targeting OX40; 5.2. Genetic evidence for the involvement of the OX40-OX40L interaction in human disease; 6. Summary and Future Perspectives; References

Chapter 4: The Family of IL-10-Secreting CD4+ T Cells

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786612770180

9781282770188

1282770187

9780123813039

0123813034

OCLC:

700688779