Pharmacology of purine and pyrimidine receptors / edited by Kenneth A. Jacobson, Joel Linden.

Format:

Book

Contributor:

Jacobson, Kenneth A.

Linden, Joel.

Series:

Advances in pharmacology (San Diego, Calif.) ; 61.

Advances in pharmacology ; 61

Language:

English

Subjects (All):

Nucleotides.

Purine nucleotides--Receptors--Effect of drugs on.

Purine nucleotides.

Pyridine nucleotides--Receptors--Effect of drugs on.

Pyridine nucleotides.

Pharmacology.

Physical Description:

1 online resource (558 p.)

Edition:

1st ed.

Place of Publication:

San Diego, Calif. : Elsevier, 2011.

Language Note:

English

Summary:

This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. Authors are the leading authorities in their fields Subject matter is important for understanding tissue protection Subject matter is of intense interest for new drug development

Contents:

Front Cover; Pharmacology of Purineand Pyrimidine Receptors; Copyright; Contents; Contributors; Preface; References; Chapter 1: The Structure of the Adenosine Receptors; I. Introduction; II. Primary Sequence and Covalent Modifications of the Adenosine A2A Receptors; III. The A2AAR Crystal Structure; IV. Binding Selectivity Across the ARs; V. Receptor Structure and Receptor Homology Modeling; VI. In Silico Screening; VII. Conclusion; References; Chapter 2: Adenosine Receptors in Health and Disease; I. Introduction; II. A1 Adenosine Receptors; III. A2A Adenosine Receptors

IV. A2B Adenosine ReceptorsV. A3 Adenosine Receptors; VI. Conclusion; References; Chapter 3: Adenosine and the Regulation of Metabolism and Body Temperature; I. Introduction. The Concept of Adenosine as an Emergency Signal; II. Adenosine and the Regulation of Lipid Metabolism; III. Adenosine and Glucose Homeostasis; IV. Central Regulation of Metabolism, Sleep, and Wakefulness; V. Regulation of Temperature; VI. Conclusion; Acknowledgments; References; Chapter 4: Regulation of Leukocyte Function by Adenosine Receptors; I. Introduction; II. Immune Responses to Adenosine Receptor Signaling

III. Disease Relevance of Adenosine to Immune SignalingIV. Conclusion; Disclosure Statement; References; Chapter 5: Receptors in Inflammation; I. Introduction; II. Tools to Study A2B Adenosine Receptor Function; III. A2B Receptors on Immune Cells; IV. A2B Receptors on Endothelial Cells; V. A2B Receptors on Epithelial Cells; VI. Role of A2B Receptors on Fibroblasts; VII. Role of A2B Receptors in Animal Models of Inflammation; VIII. Conclusions; Acknowledgments; References; Chapter 6: Adenosine Receptors in Tissue Protection; I. Introduction; II. Relationship Between Hypoxia and Inflammation

III. Effect of Hypoxia on the Extracellular Availability of AdenosineIV. Alteration of ADORA2B Signaling by Hypoxia; V. Examples of ADORA2B Signaling in Tissue Protection from Hypoxia; VI. Other ARs than the ADORA2B During Hypoxia; VII. Conclusion; Acknowledgment; References; Chapter 7: Allosteric Modulation of Purine and Pyrimidine Receptors; I. Introduction; II. AR Modulators; III. ""Translational"" Assessment of a Prototypical PAM of A1 AR; IV. Allosteric Modulators of P2Y and P2X Receptors for Nucleotides; V. Conclusion; Acknowledgments; References

Chapter 8: Molecular Mechanisms of Purine and Pyrimidine Nucleotide ReleaseI. Introduction; II. Nucleotide Release Is a Feature of Living Cells; III. Mechanisms of Nucleotide Release; IV. Conclusion; Acknowledgments; References; Chapter 9: Impact of Ectoenzymes on P2 and P1 Receptor Signaling; I. Introduction; II. Enzymes Metabolizing Extracellular Nucleotides; III. Examples of Physiological Roles of Ectoenzymes in P2 and P1 Signaling; IV. Note on Ectonucleotidase Inhibitor Development; V. Conclusion; Acknowledgments; References

Chapter 10: Ectonucleotidases as Regulators of Purinergic Signaling in Thrombosis, Inflammation, and Immunity

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-283-11474-7

9786613114747

0-12-385533-0

OCLC:

730151735