Immunity to Listeria monocytogenes / edited by Emil R. Unanue, Javier A. Carrero.

Format:

Book

Contributor:

Unanue, Emil R., 1934-

Carrero, Javier A.

Series:

Advances in immunology ; v. 113.

Advances in immunology, 0065-2776 ; v. 113

Language:

English

Subjects (All):

Listeria monocytogenes.

Immune system.

Foodborne diseases.

Physical Description:

1 online resource (206 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam : Elsevier/Academic Press, 2012.

Language Note:

English

Summary:

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the lates

Contents:

Front cover; Advances in Immunology: Immunity to Listeria monocytogenes; Copyright; Contents; Contributors; Chapter 1: Studies with Listeria Monocytogenes Lead the Way; References; Chapter 2: Interactions of Listeria monocytogenes with the Autophagy System of Host Cells; 1. Introduction; 2. Phagosome Escape; 2.1. Bacterial factors; 2.2. Host factors facilitating escape from the phagosome; 3. Autophagy and L. monocytogenes; 4. Conclusion; References; Chapter 3: Virulence Factors That Modulate the Cell Biology of Listeria Infection and the Host Response; 1. Introduction

2. The Cell Biology of Listeria Infection2.1. Listeria invasion and the new role for clathrin and septins; 2.2. Escape from the vacuole; 2.3. Actin-based motility and cell-to-cell spread; 3. Bacterial Interaction with Host Defenses; 3.1. Escape from intracellular immunity; 3.2. Escape from autophagy; 3.3. Posttranslational modifications in infected cells; 3.4. Gene reprogramming: Histone modifications and chromatin remodeling; 4. Conclusions and Perspectives; References; Chapter 4: Dendritic Cells in Listeria monocytogenes Infection; 1. Introduction; 1.1. DC development; 1.2. DC subsets

1.3. Monocyte-derived DCs2. DCs in Establishment of Lm Infection; 2.1. Splenic architecture; 2.2. Splenic DC infection by Lm; 2.3. Splenic CD8a+ DC localization; 2.4. Splenic CD8a+ DCs are required for Lm infection; 2.5. Peripheral tissue DCs during Lm infection; 3. DC Cytokine Production During Lm Infection; 3.1. pDCs during Lm infection; 3.2. IL-12 production during Lm infection; 4. DCs as Antigen-Presenting Cells During Lm Infection; 5. Conclusions; Note added in proof; References; Chapter 5: Probing CD8 T Cell Responses with Listeria monocytogenes Infection; 1. Introduction

2. Recombinant L. monocytogenes as a Versatile Vehicle to Probe Antigen-specific CD8 T Cell Responses3. Primary CD8 T Cell Responses; 3.1. CD8 T cell expansion; 3.1.1. Programming of T cell expansion; 3.1.2. Effector molecules and CD8 T cell expansion; 3.1.3. Inflammation and CD8 T cell expansion; 3.2. CD8 T cell contraction; 3.2.1. Programming of CD8 T cell contraction; 3.2.2. Factors determining survival from contraction; 4. Memory CD8 T Cell Responses; 4.1. Memory CD8 T cell generation; 4.2. Memory CD8 T cell maintenance

4.3. Diversification of memory CD8 T cells upon multiple antigen stimulations5. Surrogate Markers to Track Antigen-specific CD8 T Cell Responses; 6. Future Directions; 6.1. L. monocytogenes as a model for mucosal CD8 T cell responses; 6.2. L. monocytogenes as a live vaccine vector; 7. Conclusion; Acknowledgments; References; Chapter 6: Listeria monocytogenes and Its Products as Agents for Cancer Immunotherapy; 1. The Challenge of Tumor Immunotherapy; 2. The Biology of L. monocytogenes; 2.1. L. monocytogenes as a vaccine vector for cancer

2.2. Listeria targeting HPV-16 E7 as a vaccine for cervical cancer

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613434197

9781283434195

1283434199

9780123947987

0123947987

OCLC:

775872711