Growth factors in development / edited by Carmen Birchmeier.

Format:

Book

Contributor:

Birchmeier, Carmen.

Series:

Current topics in developmental biology ; v. 97.

Current topics in developmental biology, 0070-2153 ; v. 97

Language:

English

Subjects (All):

Growth factors.

Physical Description:

1 online resource (269 p.)

Edition:

1st ed.

Place of Publication:

San Diego, Calif. : Elsevier, 2011.

Language Note:

English

Summary:

This new volume of the renowned serial Current Topics in Developmental Biology covers the important features of growth factors in development. With an international board of authors, this volume will be invaluable for researchers in cell, developmental and molecular biology.Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the areaThis volume provides an up-to-date and timely perspective

Contents:

Front Cover; Growth Factors in Development; Copyright; Contents; Contributors; Preface; Chapter 1: New Insights into Siganling During Myelination in Zebrafish; 1. Introduction; 2. Schwann Cell Development; 3. Neuregulin1/ErbB Signaling; 4. Gpr126; 5. New Roles for Schwann Cells; 6. Oligodendrocytes; 7. Conclusions and Future Directions; Acknowledgents; References; Chapter 2: Wnt Signaling: Signaling at andAbove the Receptor Level; 1. Overview of Wnt Signal TransductionCascades; 2. Wnt Proteins: Different Branchesof Signaling; 3. Regulation of Wnt Signaling Above theReceptor Level

4. Regulation of Wnt SignalingPathways at the Receptor Level5. Conclusions and Perspective; Acknowledgments; References; Chapter 3: Notch-Independent Functions of CSL; 1. Introduction; 2. CSL as a Repressor; 3. CSL as a Notch-Independent Transcriptional Activator; 4. Role of cis-Regulatory Modules in Determining Target Gene Transcription; 5. Role of Competition Between CSL-Containing Complexes-Is CSL a Limiting Factor?; 6. Concluding Remarks; Acknowledgments; References; Chapter 4: Sonic Hedgehog Signaling inthe Developing CNS: Where ItHas Been and Where It Is Going

1. Prologue: Identification of Shh2. Setting the Stage: Shh Signaling DuringNervous System Regionalization; 3. I Am Dying to Hear from You: The Rangeof Shh Signaling in the CNS; 4. Character Creation: Production andSecretion of Shh Protein; 5. Won't You Take My Hand: Shh-Binding Proteins and Diffusion; 6. Character Development: Transductionof Shh Signal in Receiving Cells; 7. Cutting in on the Dance: The Interplay Between PTC and Smo; 8. Taking It to the Extreme: The Central Roleof the Primary Cilium in SHH Signaling; 9. Stepping into the Dark: How Does Smo Control Gli Phosphorylation?

10. Are You Going to Use That Thing? Smoas a G-Protein-Coupled Receptor11. Being in the Right Place at the Right Time:Shh-Gli Signaling and Patterning in theVentral Neural Tube; 12. Walking Down the Runway: A Model forShh-Gli Control of Early ProgenitorPatterning; 13. What's It Gonna Be, Boy? GliA VersusGliR-Regulated Genes; 14. New Game: Distinct Mechanisms forGliA-and GliR-Mediated Transcription; 15. Summary and Further Questions; Reference; Chapter 5: Activity-Mediated Synapse Formation:A Role for Wnt-Fz Signaling; 1. Introduction; 2. Wnts and Their Receptors

3. The Role of Wnt Signaling inSynapse Formation4. Role of Neuronal Activity in Wnt-MediatedDendrite Morphogenesis; 5. Role of Neuronal Activity inWnt-Mediated Synapse Formation; 6. Concluding Remarks; Acknowledgments; References; Chapter 6: Signaling Pathways and AxisFormation in the Lower Metazoa; 1. Introduction; 2. Animal Relationships and the Origin of theBasal Metazoa; 3. Wnt Signaling; 4. TGF-b and BMP Signaling; 5. Negative Regulators of BMP and WntSignaling; 6. Axis Formation and Regeneration in BasalMetazoans; 7. Conclusions and Outlook; Acknowledgment; References

Chapter 7: FGF and ROR2 Receptor TyrosineKinase Signaling in Human Skeletal Development

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613347909

9781283347907

1283347903

9780123859761

012385976X

OCLC:

775872001